Menopause – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:22:30 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Menopause – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 A study of estradiol and progesterone treatment for blood sugar control in women with type 1 or type 2 diabetes during or after menopause https://clinicaltrials.eu/trial/a-study-of-estradiol-and-progesterone-treatment-for-blood-sugar-control-in-women-with-type-1-or-type-2-diabetes-during-or-after-menopause/ Wed, 29 Apr 2026 15:08:16 +0000 https://clinicaltrials.eu/trial/a-study-of-estradiol-and-progesterone-treatment-for-blood-sugar-control-in-women-with-type-1-or-type-2-diabetes-during-or-after-menopause/ This study involves women going through or after menopause who also have diabetes mellitus, which can be either type 1 diabetes or type 2 diabetes. Diabetes is a condition where the body has trouble controlling blood sugar levels. Menopause is the time in a woman’s life when her monthly periods stop, and this can cause various symptoms such as hot flushes, sweating, joint pain, low mood, and changes in sexual desire. The study will use two medications: estradiol, which is given through patches placed on the skin, and progesterone, which is taken as capsules by mouth. These are hormones that naturally decrease during menopause.

The purpose of this study is to find out how these hormone medications affect blood sugar control in women with diabetes who are experiencing menopause symptoms. The study will look at whether using estradiol patches combined with progesterone capsules helps to keep blood sugar levels within a healthy range. During the study, participants will have periods where they receive the hormone treatment and periods where they do not receive treatment. Blood sugar levels will be measured continuously using a monitoring device worn on the body for two weeks at different times during the study.

The study will also look at other health measures, including how well insulin works in the body, changes in blood pressure, cholesterol levels, liver fat content, muscle strength, and various symptoms related to menopause and diabetes. Participants will complete questionnaires about their symptoms, sleep quality, mood, and overall quality of life. Some participants will undergo additional tests such as an MRI scan to measure liver fat and specialized tests to measure how the body responds to insulin. The entire treatment period will last up to 60 months, during which participants will be monitored to see how the hormone treatment affects their diabetes control and overall health.

]]> Evaluation of triptorelin, estradiol, and testosterone compared to placebo for changes in bone markers in postmenopausal women https://clinicaltrials.eu/trial/comparing-triptorelin-injection-transdermal-estradiol-and-transdermal-testosterone-with-placebo-to-study-bone-markers-in-postmenopausal-women/ Wed, 29 Apr 2026 15:06:21 +0000 https://clinicaltrials.eu/trial/comparing-triptorelin-injection-transdermal-estradiol-and-transdermal-testosterone-with-placebo-to-study-bone-markers-in-postmenopausal-women/ This study focuses on women experiencing menopause, a natural process when menstrual periods permanently stop. The research aims to compare the effects of different treatments on bone health in postmenopausal women. The treatments being tested include triptorelin (a hormone-regulating medication given as an injection), estradiol (a female hormone applied as a gel on the skin), testosterone (a hormone also applied as a gel on the skin), and placebo.

The study involves four different groups of participants, with each group receiving one of the treatments mentioned above. The medications are administered over an 8-week period. Triptorelin is given as an injection into the muscle, while both estradiol and testosterone are applied to the skin as gels. Some participants will receive placebo treatment instead of active medication.

During the study, researchers will monitor changes in bone health markers and other body functions. The study will also track changes in various aspects of participants’ health, including hormone levels, quality of life, sleep patterns, and other health indicators. Regular check-ups and blood tests will be performed to ensure participant safety throughout the study period.

]]> Study on the Effects of DHEA and Melatonin on Sleep and Mood in Postmenopausal Women with Sleep Disorders https://clinicaltrials.eu/trial/study-on-the-effects-of-dhea-and-melatonin-on-sleep-and-mood-in-postmenopausal-women-with-sleep-disorders/ Wed, 29 Apr 2026 15:03:53 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-dhea-and-melatonin-on-sleep-and-mood-in-postmenopausal-women-with-sleep-disorders/ This clinical trial is focused on studying the effects of a combination treatment on sleep quality and mood in women who have gone through menopause. Menopause is a natural phase in a woman’s life when her menstrual periods stop permanently, and she can no longer become pregnant. During this time, many women experience sleep disorders and mood changes. The treatment being studied includes two medications: DHEA (20 mg) and melatonin (2 mg), which is a prolonged-release tablet. DHEA is a hormone that the body naturally produces, and melatonin is a hormone that helps regulate sleep.

The purpose of this study is to see if taking these medications together for 12 weeks can improve sleep quality and mood in postmenopausal women. The study will also look at whether this combination can reduce daytime sleepiness and the severity of symptoms like hot flashes, which are common during menopause. Participants will be randomly assigned to receive either the medication combination or a placebo, and neither the participants nor the researchers will know who is receiving which treatment until the study is completed.

Throughout the study, participants will take the medication or placebo orally, meaning by mouth, for a period of 12 weeks. The study will monitor changes in sleep quality, mood, and menopausal symptoms. Additionally, the study will assess the effects of the treatment on certain hormone levels in the blood. This research aims to provide more information on how these medications might help improve the quality of life for women experiencing menopause-related issues.

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