Menopausal symptoms – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:23:25 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Menopausal symptoms – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Relative bioavailability and safety of elinzanetant soft‑gel capsules in healthy adults for vasomotor symptoms https://clinicaltrials.eu/trial/relative-bioavailability-and-safety-of-elinzanetant-soft-gel-capsules-in-healthy-adults-for-vasomotor-symptoms/ Fri, 05 Jun 2026 04:02:49 +0000 https://clinicaltrials.eu/trial/relative-bioavailability-and-safety-of-elinzanetant-soft-gel-capsules-in-healthy-adults-for-vasomotor-symptoms/ The study looks at a condition called vasomotor symptoms, which are hot flashes and night sweats that can happen when sex hormones change in women and men. The medication being examined is an oral pill that contains the active ingredient elinzanetant, also known by its code name BAY 3427080, and it is provided in a soft gel capsule form.

The purpose of the study is to compare how much of the medication is absorbed into the bloodstream from different capsule formulations. Participants will take a single dose of each capsule type while fasting, meaning they will not eat for several hours before taking the medicine, and the study will follow a simple schedule where each dose is given at separate times.

Researchers will watch for any adverse events, which are side effects or unwanted reactions, and will record how often they occur and how severe they are, while also measuring how much of the drug reaches the blood to understand its bioavailability.

]]> Study on the Effects of Estetrol Monohydrate on Hair Growth in Postmenopausal Women with Hair Loss https://clinicaltrials.eu/trial/study-on-the-effects-of-estetrol-monohydrate-on-hair-growth-in-postmenopausal-women-with-hair-loss/ Wed, 29 Apr 2026 15:05:38 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-estetrol-monohydrate-on-hair-growth-in-postmenopausal-women-with-hair-loss/ This clinical trial is focused on studying the effects of a treatment on female pattern hair loss in postmenopausal women. The treatment being tested is a 20 mg tablet of estetrol monohydrate, a chemical compound, and it will be compared to a placebo. The purpose of the study is to assess how this treatment influences hair growth parameters over a period of six months.

Participants in the study will be randomly assigned to receive either the estetrol monohydrate tablet or a placebo. The study is designed to be double-blind, meaning neither the participants nor the researchers will know who is receiving the actual treatment or the placebo. The main focus will be on measuring changes in hair growth, specifically looking at the number and width of non-vellus hair, which is the thicker type of hair, at the end of the study period. Additionally, the study will evaluate the safety of the treatment and its effects on the endometrium, which is the lining of the uterus, as well as monitor any vaginal bleeding in participants who have not had a hysterectomy.

The study will last for approximately six months, during which participants will be asked to maintain their usual hair care routines and hairstyles. Regular assessments will be conducted to monitor hair growth and overall health. The study aims to provide valuable insights into the potential benefits and safety of estetrol monohydrate for improving hair growth in postmenopausal women experiencing hair loss.

]]> Study on How Elinzanetant Affects Dabigatran Etexilate in Healthy Volunteers with Vasomotor Symptoms https://clinicaltrials.eu/trial/study-on-how-elinzanetant-affects-dabigatran-etexilate-in-healthy-volunteers-with-vasomotor-symptoms/ Wed, 29 Apr 2026 15:05:18 +0000 https://clinicaltrials.eu/trial/study-on-how-elinzanetant-affects-dabigatran-etexilate-in-healthy-volunteers-with-vasomotor-symptoms/ This clinical trial is focused on understanding how the study drug elinzanetant (also known by its code name BAY 3427080) affects the way another drug, dabigatran etexilate, moves into, through, and out of the body. The study involves healthy male and female participants. Elinzanetant is being studied for its potential effects on vasomotor symptoms, which are symptoms like hot flashes that can occur due to changes in hormone levels in both women and men.

The purpose of the study is to investigate the effect of a single dose of elinzanetant on the exposure of dabigatran etexilate in the body. Participants will receive a single dose of elinzanetant and then the movement of dabigatran etexilate in their bodies will be monitored. The study will help researchers understand how these two drugs interact when taken together.

During the study, participants will be monitored for any side effects or adverse events that may occur. The study aims to ensure the safety of participants while gathering important information about how these drugs work together. This research is important for developing better treatments for managing symptoms related to hormone changes.

]]> Study on the Safety of Micronized Progesterone and Norethisterone Acetate with Estradiol for Menopausal Symptoms in Women https://clinicaltrials.eu/trial/study-on-the-safety-of-micronized-progesterone-and-norethisterone-acetate-with-estradiol-for-menopausal-symptoms-in-women/ Wed, 29 Apr 2026 15:04:00 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-of-micronized-progesterone-and-norethisterone-acetate-with-estradiol-for-menopausal-symptoms-in-women/ This clinical trial is focused on studying the safety of treatments for women experiencing menopausal symptoms, such as hot flashes, sweating, and sleep problems. The study involves two main treatments: oral micronized progesterone and norethisterone acetate, both used in combination with estradiol, a form of estrogen. The purpose of the study is to compare the effects of these treatments on breast and endometrial health over a one-year period.

Participants in the study will be randomly assigned to receive either the progesterone or norethisterone acetate treatment, along with estradiol. The study is designed to be double-blind, meaning neither the participants nor the researchers will know which treatment is being given to each participant. This helps ensure that the results are unbiased. The study will also include a placebo, which is a substance with no active medication, to help compare the effects of the treatments.

Throughout the study, participants will undergo regular check-ups to monitor their health, including mammograms to assess breast density and ultrasounds to evaluate the thickness of the endometrium, which is the lining of the uterus. The study aims to provide valuable information on the safety and effects of these hormone therapies for managing menopausal symptoms.

]]> Study on the Effects of DHEA and Melatonin on Sleep and Mood in Postmenopausal Women with Sleep Disorders https://clinicaltrials.eu/trial/study-on-the-effects-of-dhea-and-melatonin-on-sleep-and-mood-in-postmenopausal-women-with-sleep-disorders/ Wed, 29 Apr 2026 15:03:53 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-dhea-and-melatonin-on-sleep-and-mood-in-postmenopausal-women-with-sleep-disorders/ This clinical trial is focused on studying the effects of a combination treatment on sleep quality and mood in women who have gone through menopause. Menopause is a natural phase in a woman’s life when her menstrual periods stop permanently, and she can no longer become pregnant. During this time, many women experience sleep disorders and mood changes. The treatment being studied includes two medications: DHEA (20 mg) and melatonin (2 mg), which is a prolonged-release tablet. DHEA is a hormone that the body naturally produces, and melatonin is a hormone that helps regulate sleep.

The purpose of this study is to see if taking these medications together for 12 weeks can improve sleep quality and mood in postmenopausal women. The study will also look at whether this combination can reduce daytime sleepiness and the severity of symptoms like hot flashes, which are common during menopause. Participants will be randomly assigned to receive either the medication combination or a placebo, and neither the participants nor the researchers will know who is receiving which treatment until the study is completed.

Throughout the study, participants will take the medication or placebo orally, meaning by mouth, for a period of 12 weeks. The study will monitor changes in sleep quality, mood, and menopausal symptoms. Additionally, the study will assess the effects of the treatment on certain hormone levels in the blood. This research aims to provide more information on how these medications might help improve the quality of life for women experiencing menopause-related issues.

]]> Study on the Effects of Estradiol, Progesterone, and Online Sleep Therapy for Insomnia and Menopausal Symptoms in Perimenopausal Women https://clinicaltrials.eu/trial/study-on-the-effects-of-estradiol-progesterone-and-online-sleep-therapy-for-insomnia-and-menopausal-symptoms-in-perimenopausal-women/ Wed, 29 Apr 2026 15:03:34 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-estradiol-progesterone-and-online-sleep-therapy-for-insomnia-and-menopausal-symptoms-in-perimenopausal-women/ This clinical trial is focused on understanding how different treatments can help with insomnia and climacteric symptoms, which are common during the perimenopause phase. Perimenopause is the time when a woman’s body transitions towards menopause, often leading to sleep problems and mood changes. The study will explore the effects of two treatments: a hormone therapy using a transdermal patch called Systen 50, which contains estradiol, and a capsule called Utrogestan, which contains progesterone. Additionally, the study will include a guided online program designed to improve sleep and mood.

The purpose of the study is to evaluate how effective these treatments are, both individually and in combination, in improving sleep and mood in women experiencing perimenopause. Participants will use the hormone therapy and the online program over a period of time, and their progress will be monitored. The study will also use devices like the Hypnodyne ZMax Total and the Empatica EmbracePlus wristband to track sleep patterns and other health indicators at home.

The study will last several months, with participants being assessed at different stages to see how their symptoms change over time. The goal is to find ways to reduce mental health complaints and improve overall well-being for women going through perimenopause. This research aims to provide valuable insights into managing symptoms associated with this phase of life.

]]> Study on Elinzanetant for Treating Sleep Disturbances in Menopausal Women https://clinicaltrials.eu/trial/study-on-elinzanetant-for-treating-sleep-disturbances-in-menopausal-women/ Wed, 29 Apr 2026 14:47:57 +0000 https://clinicaltrials.eu/trial/study-on-elinzanetant-for-treating-sleep-disturbances-in-menopausal-women-2/ This clinical trial is focused on studying sleep disturbances associated with menopause. The treatment being tested is a medication called elinzanetant, which is being compared to a placebo. The purpose of the study is to learn about how elinzanetant works and how safe it is for women experiencing sleep problems during menopause.

Participants in the study will be randomly assigned to receive either elinzanetant or a placebo. The study will last for several weeks, during which participants will take the medication in the form of a soft capsule. Throughout the study, participants will be monitored to assess any changes in their sleep patterns and overall well-being.

The study aims to explore the effectiveness of elinzanetant in improving sleep quality for women who are in the post-menopausal period. By the end of the study, researchers hope to gather valuable information on whether elinzanetant can help alleviate sleep disturbances associated with menopause.

]]> Study on the Required Dose of Cholecalciferol for Managing Vitamin D Deficiency in Postmenopausal Women https://clinicaltrials.eu/trial/study-on-the-required-dose-of-cholecalciferol-for-managing-vitamin-d-deficiency-in-postmenopausal-women/ Wed, 29 Apr 2026 14:24:02 +0000 https://clinicaltrials.eu/trial/study-on-the-required-dose-of-cholecalciferol-for-managing-vitamin-d-deficiency-in-postmenopausal-women/ This clinical trial is focused on studying the effects of a treatment for vitamin D deficiency and insufficiency in postmenopausal women. The treatment being tested is a medication called Cholecalciferol, which is a form of vitamin D. The purpose of the study is to determine the required dose of Cholecalciferol to effectively manage vitamin D levels in women who have gone through menopause and are experiencing low levels of this important vitamin.

Participants in the study will take Cholecalciferol in the form of soft capsules, known as Lundeos 20,000 UI. The study will involve several visits where vitamin D levels in the blood will be measured to see how well the treatment is working. The study will also look at how satisfied participants are with the treatment. The treatment is taken orally, which means it is swallowed like a regular pill.

The study will help to understand how much Cholecalciferol is needed to maintain healthy vitamin D levels in postmenopausal women. This is important because vitamin D plays a crucial role in bone health and overall well-being. By participating in this study, researchers hope to find the best way to support women who are experiencing vitamin D deficiency or insufficiency after menopause.

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