Medication overuse headache – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:33:22 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Medication overuse headache – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of Eptinezumab as Add-on Treatment for Prevention of Migraine in Adults with Both Migraine and Medication Overuse Headache https://clinicaltrials.eu/trial/study-of-eptinezumab-for-preventing-migraine-in-patients-with-migraine-and-medication-overuse-headache/ Wed, 29 Apr 2026 14:30:32 +0000 https://clinicaltrials.eu/trial/study-of-eptinezumab-for-preventing-migraine-in-patients-with-migraine-and-medication-overuse-headache/ This study focuses on people who have both chronic migraine and medication overuse headache. Medication overuse headache occurs when people frequently use headache medications, which can actually lead to more frequent headaches. The study will test a medicine called eptinezumab (also known as VYEPTI or Lu AG09221), which is given through an intravenous infusion for migraine prevention.

The purpose of this research is to determine if eptinezumab, when combined with basic education about headaches, can help prevent migraines and treat medication overuse headaches. During the study, participants will receive either eptinezumab or placebo as an addition to educational information about headache management. The medication or placebo will be given through an infusion into a vein.

The study will last for 72 weeks, during which participants may receive up to 300 milligrams of the study medication. Throughout the study, participants will need to keep track of their headaches and medication use in an electronic diary. The researchers will monitor how the treatment affects both the frequency of migraines and the overuse of headache medications.

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