Mechanical ventilation – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 18 Jun 2026 04:08:03 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Mechanical ventilation – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of ketamine hydrochloride to improve recovery in adults requiring unplanned mechanical ventilation in the intensive care unit https://clinicaltrials.eu/trial/study-of-ketamine-hydrochloride-to-improve-recovery-in-adults-requiring-unplanned-mechanical-ventilation-in-the-intensive-care-unit/ Wed, 29 Apr 2026 15:10:00 +0000 https://clinicaltrials.eu/trial/study-of-ketamine-hydrochloride-to-improve-recovery-in-adults-requiring-unplanned-mechanical-ventilation-in-the-intensive-care-unit/ This study focuses on patients in the Intensive Care Unit (ICU) who require unplanned invasive mechanical ventilation, which is a method of using a machine to help a person breathe. The goal of the study is to assess recovery from critical illness in these patients. The research compares the effects of using ketamine hydrochloride, an injectable medication, against a placebo.

Participants will receive either an infusion, which is a continuous flow of medicine through a vein, of the test medication or a sodium chloride solution. During the study, various health factors are monitored, including the use of norepinephrine or inotropes, which are medications used to support blood pressure and heart function. The study also looks at the presence of encephalopathy, a term used to describe changes in brain function such as coma or delirium, as well as the impact on kidney and liver health.

The course of the study involves tracking recovery over a period of several months. This includes monitoring the use of opioids and sedatives, which are medicines used to manage pain and sleep, and observing symptoms such as hallucinations, anxiety, depression, or post-traumatic stress disorder (PTSD). Information is collected to see how many days patients spend alive and at home, as well as how long they can breathe without the help of a machine.

]]> Study of dexmedetomidine versus placebo to reduce opioid use in premature babies requiring mechanical ventilation for respiratory distress https://clinicaltrials.eu/trial/study-of-dexmedetomidine-versus-placebo-to-reduce-opioid-use-in-premature-babies-requiring-mechanical-ventilation-for-respiratory-distress/ Wed, 29 Apr 2026 15:09:00 +0000 https://clinicaltrials.eu/trial/study-of-dexmedetomidine-versus-placebo-to-reduce-opioid-use-in-premature-babies-requiring-mechanical-ventilation-for-respiratory-distress/ This study focuses on premature infants who are experiencing neonatal respiratory distress, a condition where a newborn has difficulty breathing, and who require invasive ventilation, which is a method of using a machine to help a baby breathe through a tube. The purpose of the study is to evaluate whether the use of dexmedetomidine can reduce the total amount of opioids, such as morphine, sufentanil, or fentanyl, needed to manage pain and discomfort in these infants. Opioids are strong medications used to relieve pain.

During the study, infants will receive either dexmedetomidine or a placebo through an intravenous infusion, which means the medication is delivered directly into a vein. Participants will be assigned to one of these two groups by chance. The process involves monitoring the infants while they are receiving breathing support to see how the different treatments affect their need for pain medication and their overall comfort levels.

]]> Study on Early Sedation with Dexmedetomidine vs. Placebo for Older Critically Ill Patients on Ventilators https://clinicaltrials.eu/trial/study-on-early-sedation-with-dexmedetomidine-vs-placebo-for-older-critically-ill-patients-on-ventilators/ Wed, 29 Apr 2026 14:26:40 +0000 https://clinicaltrials.eu/trial/study-on-early-sedation-with-dexmedetomidine-vs-placebo-for-older-critically-ill-patients-on-ventilators/ This clinical trial is focused on studying the effects of early sedation in older patients who are critically ill and require intensive medical care, including the use of machines to help them breathe, known as mechanical ventilation. The study involves patients who are 65 years or older and are in need of continuous sedative medication to ensure comfort and safety while receiving life-supporting treatments. The medication being tested is called Dexmedetomidine, which is given as a solution through an infusion. This trial compares the effects of Dexmedetomidine with a placebo, which is a substance with no active medication, to see if it can improve outcomes for these patients.

The main goal of the study is to evaluate the impact of using Dexmedetomidine as a primary sedative on the survival of patients over a period of 90 days. The study will also look at other important factors, such as the number of days patients are alive without experiencing coma or delirium, the number of days they are free from the ventilator, and any major kidney problems that may occur. Additionally, the study will assess how long patients need mechanical ventilation and their length of stay in the hospital.

The trial is expected to run until December 2025, with the recruitment of participants having started in August 2023. The findings from this study could help improve the care and treatment of older patients who are critically ill and require mechanical ventilation.

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