Measles – European Clinical Trials Information Network

Study on the Effectiveness of Skin Patch Vaccination with Measles, Mumps, and Rubella Vaccine in Healthy Volunteers

Wed, 29 Apr 2026 15:05:50 +0000

This clinical trial is focused on studying the effects of the Measles, Mumps, and Rubella (MMR) vaccine. The diseases being studied are measles, mumps, and rubella, which are viral infections that can cause serious health problems. The treatment being tested is the M-M-RvaxPro vaccine, which is a live vaccine designed to protect against these three diseases. The vaccine is given as a suspension for injection, which means it is a liquid that is injected into the body.

The purpose of the study is to compare two different methods of administering the MMR vaccine to see if one method is more effective than the other. One method involves the traditional injection under the skin, while the other method involves a new approach called epicutaneous vaccination, where the vaccine is applied to the skin. The study will observe the immune response, specifically looking at the production of a type of antibody called IgA, which plays a crucial role in the body’s defense against infections. The study will also monitor other immune responses and any side effects that may occur after vaccination.

Participants in the study will receive both types of vaccine administration at different times, and their immune responses will be measured over a period of three months. The study aims to determine if the new method of applying the vaccine to the skin can generate a similar immune response to the traditional injection method. This research could potentially lead to new ways of administering vaccines in the future, making them more accessible and easier to use.

Study on Immunity to Measles and Chickenpox in Children with Cancer Using Measles, Mumps, Rubella, and Varicella Vaccines

Wed, 29 Apr 2026 15:05:22 +0000

This clinical trial is focused on children and adolescents aged 0-18 years who have been treated for pediatric cancer. The study aims to understand how well these young patients can develop immunity, which is the body’s ability to fight off infections, against two diseases: measles and chickenpox. The treatment being studied involves revaccination with vaccines that are designed to protect against these diseases. The vaccines used in this study are a combination vaccine for measles, mumps, and rubella and a separate vaccine for varicella, which is another name for chickenpox.

The purpose of the study is to examine how the immune system responds to these vaccines after cancer treatment. Participants will receive the vaccines through an injection into the muscle. The study will measure the levels of specific antibodies, which are proteins made by the immune system to fight infections, before and after the vaccination. This will help determine if the vaccines are effective in providing protection against measles and chickenpox in children who have undergone cancer treatment.

Throughout the study, researchers will compare the immune responses of the participants to those of a healthy control group. They will also look at differences in immune responses based on factors such as the type of cancer, the intensity of the cancer treatment, and whether the participants had immunity to these diseases before their cancer treatment. The study is expected to continue until 2028, providing valuable insights into the effectiveness of revaccination in young cancer survivors.