Malignant pleural effusion – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:31:30 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Malignant pleural effusion – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 A Study of Pressurized Aerosol Chemotherapy with Cisplatin and Doxorubicin for Patients with Fluid Buildup Around the Lungs Caused by Cancer https://clinicaltrials.eu/trial/a-study-of-pressurized-aerosol-chemotherapy-with-cisplatin-and-doxorubicin-for-patients-with-fluid-buildup-around-the-lungs-caused-by-cancer/ Wed, 29 Apr 2026 15:08:34 +0000 https://clinicaltrials.eu/trial/a-study-of-pressurized-aerosol-chemotherapy-with-cisplatin-and-doxorubicin-for-patients-with-fluid-buildup-around-the-lungs-caused-by-cancer/ This study involves patients with pleural carcinosis, a condition where cancer cells spread to the pleura, which is the thin tissue covering the lungs and lining the inside of the chest wall. When cancer affects this area, fluid can build up between the layers of the pleura, causing what is called a malignant pleural effusion. This fluid buildup can make breathing difficult and cause discomfort. The study will use a treatment method that delivers chemotherapy drugs directly into the chest cavity as a pressurized mist or aerosol. The chemotherapy drugs that will be used are cisplatin and doxorubicin hydrochloride, which are medicines designed to kill cancer cells. This treatment approach is called pressurized intrathoracic aerosol chemotherapy.

The purpose of the study is to see how well this aerosol chemotherapy method works at preventing the fluid from building up again in the chest, a process called pleurodesis. The treatment will be given during a surgical procedure using a technique called video-assisted thoracoscopic surgery, which uses small incisions and a camera to see inside the chest. During this procedure, the chemotherapy drugs will be delivered as an aerosol directly to the affected area in the chest. The study will check how effective this treatment is at controlling the fluid buildup at different time points after the procedure.

Patients in the study will be monitored for several months after receiving the treatment. The study doctors will evaluate whether the fluid in the chest is controlled and will also watch for any side effects or complications that might occur during or after the procedure. The study will also record information about the overall safety of this treatment method and will follow patients to see how they are doing at different time points after the surgery.

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