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	<title>Lower respiratory tract infection &#8211; European Clinical Trials Information Network</title>
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	<title>Lower respiratory tract infection &#8211; European Clinical Trials Information Network</title>
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		<title>Evaluating Different Durations of Antibiotic Treatment for Respiratory Tract Infections and Rhinosinusitis in Adults Receiving Beta-lactam Antibiotics</title>
		<link>https://clinicaltrials.eu/trial/evaluating-different-durations-of-antibiotic-treatment-for-respiratory-tract-infections-and-rhinosinusitis-in-adults-receiving-beta-lactam-antibiotics/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:06:37 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/evaluating-different-durations-of-antibiotic-treatment-for-respiratory-tract-infections-and-rhinosinusitis-in-adults-receiving-beta-lactam-antibiotics/</guid>

					<description><![CDATA[This study focuses on treating Acute Lower Respiratory Tract Infection and Acute Rhinosinusitis (infections affecting the airways and sinuses) with beta-lactam antibiotics. The research aims to determine the most effective duration of antibiotic treatment for these respiratory infections when treated in primary care settings. The study examines whether shorter antibiotic treatment periods can be as [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This study focuses on treating <b>Acute Lower Respiratory Tract Infection</b> and <b>Acute Rhinosinusitis</b> (infections affecting the airways and sinuses) with <b>beta-lactam antibiotics</b>. The research aims to determine the most effective duration of antibiotic treatment for these respiratory infections when treated in primary care settings.</p>
<p>The study examines whether shorter antibiotic treatment periods can be as effective as standard longer treatments. Patients will receive antibiotics through <b>oral</b> administration for different durations, with some patients taking the medication for a shorter time than others. The maximum treatment period will be 14 days.</p>
<p>During the study, patients will be monitored to see if their symptoms improve, particularly checking for the disappearance of fever and overall improvement in their condition. The study will track how quickly patients feel better and whether they need any additional treatment. Patients will keep a diary to record their symptoms and any side effects they experience during the treatment period.</p>
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		<title>Study on the Safety and Immune Response of mRNA-1345 and mRNA-1365 for Infants with Acute Lower Respiratory Infection Aged 5 to 24 Months</title>
		<link>https://clinicaltrials.eu/trial/study-on-the-safety-and-immune-response-of-mrna-1345-and-mrna-1365-for-infants-with-acute-lower-respiratory-infection-aged-5-to-24-months/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:05:43 +0000</pubDate>
				<category><![CDATA[Vaccine]]></category>
		<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-the-safety-and-immune-response-of-mrna-1345-and-mrna-1365-for-infants-with-acute-lower-respiratory-infection-aged-5-to-24-months/</guid>

					<description><![CDATA[This clinical trial is focused on studying the safety and effectiveness of two investigational vaccines, mRNA-1345 and mRNA-1365, in young children aged 5 months to less than 24 months. These vaccines are being tested to see how well they work in preventing infections caused by respiratory viruses, specifically those that can lead to acute lower [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on studying the safety and effectiveness of two investigational vaccines, <i>mRNA-1345</i> and <i>mRNA-1365</i>, in young children aged 5 months to less than 24 months. These vaccines are being tested to see how well they work in preventing infections caused by respiratory viruses, specifically those that can lead to <i>acute lower respiratory infection</i>, which is a condition affecting the lungs and airways.</p>
<p>The study involves giving participants injections of the vaccines and monitoring them for any reactions or side effects. Some participants will receive the actual vaccines, while others will receive a <i>placebo</i>, which is a substance with no active ingredients. The purpose of the study is to evaluate the safety and how the body responds to these vaccines, which are designed to help the immune system fight off infections.</p>
<p>Throughout the study, participants will be closely observed for any signs of illness or adverse reactions. The study aims to gather information on how the vaccines affect the immune system and whether they can help prevent serious respiratory infections in young children. This research is important for developing new ways to protect children from these infections and improve their overall health.</p>
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		<title>Study on Preventing Respiratory Infections and Wheezing in Late-Moderate Preterm Infants Using Bacterial Lysates</title>
		<link>https://clinicaltrials.eu/trial/study-on-preventing-respiratory-infections-and-wheezing-in-late-moderate-preterm-infants-using-bacterial-lysates/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:02:28 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-preventing-respiratory-infections-and-wheezing-in-late-moderate-preterm-infants-using-bacterial-lysates/</guid>

					<description><![CDATA[This clinical trial is focused on studying how to protect infants born a little early, known as moderate-late preterm infants, from getting sick with lower respiratory tract infections and experiencing wheezing during their first year of life. The treatment being tested is a medication called BRONCHO-VAXOM Kinderen, which comes in the form of hard capsules. [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on studying how to protect infants born a little early, known as <i>moderate-late preterm infants</i>, from getting sick with <i>lower respiratory tract infections</i> and experiencing wheezing during their first year of life. The treatment being tested is a medication called <i>BRONCHO-VAXOM Kinderen</i>, which comes in the form of hard capsules. This medication contains special ingredients known as <i>lyophilized bacterial lysates</i>, which are tiny parts of bacteria that have been dried and are used to help the body’s immune system learn to fight off infections better.</p>
<p>The purpose of the study is to see if giving these bacterial lysates to preterm infants can help reduce the number of respiratory infections and wheezing episodes they experience. The study will involve giving the medication to the infants and observing them over a period of time to see if it helps in reducing these health issues. Some infants will receive the actual medication, while others will receive a placebo, which looks like the medication but does not contain the active ingredients. This helps researchers understand the true effect of the medication.</p>
<p>Throughout the study, researchers will monitor the infants to see how many times they get sick with respiratory infections or wheeze, and how long it takes for these symptoms to appear. They will also look at other factors like the use of additional medications, the infants&#8217; lung function, and their overall quality of life. The study aims to provide valuable information on whether this treatment can help improve the health of preterm infants by boosting their immune system early on.</p>
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		<title>Study on the Effect of Acyclovir in ICU Patients with Pneumonia and Herpes Simplex Virus Type 1 Detected in Lung Fluid</title>
		<link>https://clinicaltrials.eu/trial/study-on-the-effect-of-acyclovir-in-icu-patients-with-pneumonia-and-herpes-simplex-virus-type-1-detected-in-lung-fluid/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 14:26:58 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-the-effect-of-acyclovir-in-icu-patients-with-pneumonia-and-herpes-simplex-virus-type-1-detected-in-lung-fluid/</guid>

					<description><![CDATA[This clinical trial is focused on patients who are in the intensive care unit and require ventilation due to a type of lung infection known as pneumonia. The study is particularly interested in cases where the herpes simplex virus type 1 (HSV-1) is found in the lungs. The treatment being tested is called acyclovir, which [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on patients who are in the intensive care unit and require ventilation due to a type of lung infection known as <i>pneumonia</i>. The study is particularly interested in cases where the <i>herpes simplex virus type 1 (HSV-1)</i> is found in the lungs. The treatment being tested is called <i>acyclovir</i>, which is given through an infusion directly into the bloodstream. Acyclovir is an antiviral medication that is commonly used to treat infections caused by viruses.</p>
<p>The purpose of the study is to understand how acyclovir affects the health outcomes of these patients, specifically looking at survival rates over a 30-day period. Participants in the study will receive either acyclovir or a placebo, and their progress will be monitored over time. The study will also track other factors such as the number of days patients can breathe without the help of a machine, the length of their stay in the hospital, and their overall quality of life during and after the treatment.</p>
<p>Throughout the study, researchers will collect data to see if acyclovir helps reduce the presence of HSV-1 in the lungs and improves the patients&#8217; recovery. The study aims to provide valuable insights into the potential benefits of using acyclovir for patients with pneumonia and HSV-1, ultimately helping to improve treatment strategies for these serious conditions.</p>
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		<title>Study on Oxygen Levels for Children and Adolescents with Respiratory Distress: Focusing on Bronchiolitis, Viral Wheeze, and Lower Respiratory Tract Infection</title>
		<link>https://clinicaltrials.eu/trial/study-on-oxygen-levels-for-children-and-adolescents-with-respiratory-distress-focusing-on-bronchiolitis-viral-wheeze-and-lower-respiratory-tract-infection/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 14:24:03 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-oxygen-levels-for-children-and-adolescents-with-respiratory-distress-focusing-on-bronchiolitis-viral-wheeze-and-lower-respiratory-tract-infection/</guid>

					<description><![CDATA[This clinical trial is focused on children and adolescents who are experiencing respiratory distress, which can be caused by conditions such as bronchiolitis, viral wheeze, or a lower respiratory tract infection. The study is investigating the use of a treatment involving a medicinal gas called Conoxia Liquid, which is 100% oxygen. The purpose of the [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on children and adolescents who are experiencing <i>respiratory distress</i>, which can be caused by conditions such as <i>bronchiolitis</i>, <i>viral wheeze</i>, or a <i>lower respiratory tract infection</i>. The study is investigating the use of a treatment involving a medicinal gas called <i>Conoxia Liquid</i>, which is 100% oxygen. The purpose of the study is to determine if using a specific oxygen level target can safely reduce the length of hospital stay for these young patients.</p>
<p>Participants in the study will be children aged 6 weeks to 12 years who are hospitalized and require additional oxygen. The study will compare two different oxygen level targets to see which one is more effective in helping children recover faster. The trial will monitor various aspects of the children&#8217;s recovery, including the time it takes for them to meet all discharge criteria, the length of their hospital stay, and their overall health after leaving the hospital.</p>
<p>Throughout the study, researchers will also look at other factors such as the number of admissions to the pediatric intensive care unit (PICU), the time spent on oxygen therapy, and the duration of symptoms. Additionally, the study will consider the children&#8217;s quality of life, parental anxiety, and the economic impact of the treatment. The goal is to find a safe and effective way to manage oxygen levels in children with respiratory distress, ultimately improving their recovery and overall health.</p>
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		<title>Study on Buccalin for Preventing Recurrent Lower Respiratory Infections in Adults</title>
		<link>https://clinicaltrials.eu/trial/study-on-buccalin-for-preventing-recurrent-lower-respiratory-infections-in-adults/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 14:22:59 +0000</pubDate>
				<category><![CDATA[Vaccine]]></category>
		<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-buccalin-for-preventing-recurrent-lower-respiratory-infections-in-adults/</guid>

					<description><![CDATA[This clinical trial is focused on studying the effectiveness and safety of a medication called Buccalin in preventing Recurrent Lower Respiratory Tract Infections (RLRTIs). These infections can include conditions like acute bronchitis and flare-ups of chronic lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). The study will compare the effects of Buccalin [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on studying the effectiveness and safety of a medication called <i>Buccalin</i> in preventing <i>Recurrent Lower Respiratory Tract Infections (RLRTIs)</i>. These infections can include conditions like acute bronchitis and flare-ups of chronic lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). The study will compare the effects of Buccalin with a placebo, which is a tablet that looks like the medication but does not contain any active ingredients.</p>
<p>The purpose of the study is to gather more information about how well Buccalin works in preventing these recurrent infections. Participants in the study will be randomly assigned to receive either Buccalin or the placebo. The study will last for 12 months, during which the number of infection episodes will be monitored and compared between the two groups. Additionally, the study will look at the duration of each infection, the number of antibiotic treatments needed, and the number of sick days experienced by participants.</p>
<p>Throughout the study, participants will be asked to fill out a simple scale to rate their health condition, ranging from 0 (the worst) to 10 (the best). The safety of Buccalin will also be evaluated by monitoring any side effects that occur. This study aims to provide valuable insights into the potential benefits of Buccalin for individuals who frequently experience lower respiratory tract infections.</p>
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