Local anaesthesia – European Clinical Trials Information Network

Study on the Effects of Bupivacaine Hydrochloride Dosage on Pain and Opioid Use After Knee Replacement Surgery for Patients with Postoperative Pain

Wed, 29 Apr 2026 15:02:58 +0000

This clinical trial is focused on studying the effects of different amounts of a local anesthetic called Bupivacaine on pain management after knee replacement surgery, also known as Total Knee Arthroplasty. The study aims to compare the use of 10 milliliters versus 20 milliliters of Bupivacaine for a specific type of nerve block called the Popliteal Plexus Block. This nerve block is used alongside another technique called the Femoral Triangle Block to help manage pain after surgery.

The purpose of the study is to see if using 20 milliliters of Bupivacaine can reduce the need for pain medications, specifically opioids, within the first 24 hours after surgery. Participants will be randomly assigned to receive either 10 milliliters or 20 milliliters of the anesthetic. The study will monitor how much pain medication is needed, the level of pain experienced, and how well patients recover after their knee surgery.

Throughout the study, researchers will collect information on various aspects of recovery, such as pain levels at rest and during movement, the ability to walk with crutches, and overall recovery quality. The goal is to determine the most effective amount of Bupivacaine for managing pain and improving recovery after knee replacement surgery.

Study on Preventing Persistent Postoperative Pain in Children Using Mepivacaine Hydrochloride and Drug Combination

Wed, 29 Apr 2026 14:57:06 +0000

This clinical trial is focused on studying the effects of a specific type of pain relief method called locoregional analgesia in children who have undergone surgery for bone fractures. The main goal is to see if this method can help prevent long-lasting pain after surgery. The study involves children who have had orthopedic trauma surgery, which is a type of surgery to fix broken bones. The trial will use several medications, including nalbuphine, paracetamol, sevoflurane, sufentanil (also known as OX27), ondansetron, morphine, tramadol, mepivacaine, propofol, dexamethasone, ibuprofen, ketoprofen, soya oil, and suxamethonium. Some participants will receive a placebo.

The purpose of the study is to determine if using locoregional analgesia can reduce persistent pain after surgery. Participants will be monitored for their pain levels using a simple pain scale three months after their surgery. The study will also look at other factors, such as the presence of pain at six and twelve months after surgery, any episodes of nausea or vomiting, and the amount of pain medication needed during and after surgery. The trial will last for a period of time, with regular check-ins to assess the participants’ pain and recovery progress.

By participating in this study, researchers hope to gather valuable information on how effective locoregional analgesia is in managing post-operative pain in children. This could lead to better pain management strategies for young patients undergoing similar surgeries in the future. The study will continue until enough data is collected to make a clear conclusion about the benefits of this pain relief method.

Study on Lidocaine, Ropivacaine, and Epinephrine for Patients Undergoing Hand Surgery with Ultrasound-Guided Nerve Block

Wed, 29 Apr 2026 14:47:01 +0000

This clinical trial is focused on patients undergoing hand surgery, specifically for forearm fractures or thumb joint surgeries. The study is investigating the use of a specific type of anesthesia called the lateral infraclavicular plexus brachialis (LIC) block. This type of anesthesia is used to numb the area for surgery. The trial will compare the effects of combining two local anesthetics: ropivacaine and lidocaine. These medications are used to block pain in the surgical area, with ropivacaine being a long-acting anesthetic and lidocaine being a short-acting one.

The purpose of the study is to understand how these anesthetics work together in terms of how quickly they start working and how long their effects last. The trial will also look at how well they block both feeling and movement in the area. Patients will receive either the combination of these anesthetics or a placebo, and the study will measure the time it takes for pain to return after the anesthesia is given, as well as how long the numbness and inability to move last.

Participants in the study will receive the anesthetic solution through an injection near the nerves that control sensation and movement in the arm. The study will monitor the effects from the time the anesthesia is administered until the feeling and movement return to normal. This research aims to improve the effectiveness of anesthesia for hand surgeries, potentially leading to better pain management and recovery for patients.