Liver operation – European Clinical Trials Information Network

Study on Dalteparin Sodium and Enoxaparin Sodium for Preventing Blood Clots in Patients Undergoing Liver Surgery

Wed, 29 Apr 2026 15:02:53 +0000

This clinical trial is focused on patients undergoing liver surgery, specifically those having a part of their liver removed, known as liver resection. The study is investigating the use of two medications, dalteparin sodium and enoxaparin sodium, which are both used to prevent blood clots. These medications are given through a small injection under the skin, known as a subcutaneous injection. The purpose of the study is to determine if starting these medications before or after surgery is more effective in reducing the risk of blood clots without increasing the risk of bleeding complications.

Participants in the study will receive either dalteparin sodium or enoxaparin sodium, or a placebo, for a period of up to four weeks. The study will monitor the occurrence of blood clots, known as venous thromboembolisms, within 30 days after the liver surgery. Additionally, the study will look at other factors such as bleeding after surgery, the length of hospital stay, and the amount of blood transfusions needed.

The trial aims to provide valuable information on the best timing for starting blood clot prevention treatment in patients undergoing liver surgery. By comparing the effects of starting the medication before surgery versus after, the study hopes to improve patient outcomes and reduce complications associated with liver surgery.

Study on Lidocaine and Sodium Chloride for Patients Undergoing Liver Tumor Surgery

Wed, 29 Apr 2026 14:58:55 +0000

This clinical trial is focused on patients undergoing liver surgery due to liver tumors. The study is investigating the use of lidocaine, a local anesthetic, administered through an intravenous solution, to see if it can help improve recovery after surgery. The trial will also use sodium chloride, commonly known as saline, as part of the treatment process. The main goal is to evaluate how effective lidocaine is in helping patients recover from a minor liver surgery, known as a hepatectomy.

Participants in the study will receive either lidocaine or a placebo during their surgery. The study will monitor various aspects of recovery, such as the amount of pain medication needed in the first 24 to 48 hours after surgery, the intensity of pain experienced, and any complications that may arise. Other factors being observed include the time it takes for normal bowel movements to resume, any feelings of nausea or vomiting, and the overall length of the hospital stay.

The study will also measure the concentration of lidocaine in the blood at different times during the surgery and recovery process. The aim is to gather comprehensive data on how lidocaine affects recovery and to assess any potential side effects or adverse events. This information will help determine if lidocaine can be a beneficial addition to the recovery process for patients undergoing liver surgery.