Lichen sclerosus – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:24:52 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Lichen sclerosus – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 A study to evaluate the effectiveness of methotrexate in preventing the recurrence of dermatological vulvar intraepithelial neoplasia in women with lichen sclerosus. https://clinicaltrials.eu/trial/a-study-to-evaluate-the-effectiveness-of-methotrexate-in-preventing-the-recurrence-of-dermatological-vulvar-intraepithelial-neoplasia-in-women-with-lichen-sclerosus/ Thu, 30 Apr 2026 13:08:57 +0000 https://clinicaltrials.eu/trial/a-study-to-evaluate-the-effectiveness-of-methotrexate-in-preventing-the-recurrence-of-dermatological-vulvar-intraepithelial-neoplasia-in-women-with-lichen-sclerosus/ This study focuses on individuals with lichen sclerosus, a skin condition that can cause itching and changes to the skin, and dVIN, which is a type of skin cancer found in the vulvar area. The purpose of the study is to determine if a medication called methotrexate can help prevent the return of these skin cancer lesions. This research specifically looks at people who have already experienced recurring skin changes and have not responded well to other treatments.

Participants in the study may take methotrexate in the form of an oral tablet. During the course of the study, the condition of the skin will be monitored over several months to see if the disease remains stable or if it progresses. The research also aims to observe how well the medication is tolerated and if it helps reduce the need for topical corticosteroids, which are creams used to reduce inflammation. Additionally, biopsies, which involve taking a small sample of skin tissue for examination, may be used to study the changes in the skin cells through a process called immunohistochemistry, a method used to look for specific proteins like p53 in the tissue.

]]> Study on Clobetasol, Mometasone, and Tacrolimus for Treating Vulvar Lichen Sclerosus in Children https://clinicaltrials.eu/trial/study-on-clobetasol-mometasone-and-tacrolimus-for-treating-vulvar-lichen-sclerosus-in-children/ Wed, 29 Apr 2026 15:04:27 +0000 https://clinicaltrials.eu/trial/study-on-clobetasol-mometasone-and-tacrolimus-for-treating-vulvar-lichen-sclerosus-in-children/ This clinical trial is focused on studying the treatment of lichen sclerosus of the vulva in children and teenagers. Lichen sclerosus is a skin condition that affects the genital area, causing itching, discomfort, and changes in skin appearance. The study will test three different ointments: clobetasol propionate, mometasone furoate, and tacrolimus. These medications are applied directly to the skin to help reduce inflammation and improve symptoms.

The purpose of the study is to compare how effective and safe these treatments are for young patients. Participants will be divided into three groups, each receiving one of the ointments. The study will last for about 12 weeks, during which the participants will apply the ointment to the affected area as directed. Researchers will monitor the participants to see how well the treatments work in reducing symptoms and improving the quality of life.

Throughout the study, the impact of various factors such as age, immune system function, and genetic makeup on the treatment’s effectiveness will also be evaluated. The goal is to find the best treatment option for managing lichen sclerosus in the pediatric population, ensuring both safety and improvement in symptoms.

]]> Study on the Effectiveness and Safety of MC2-25 Cream for Women with Vulvar Lichen Sclerosus https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-mc2-25-cream-for-women-with-vulvar-lichen-sclerosus/ Wed, 29 Apr 2026 14:26:36 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-mc2-25-cream-for-women-with-vulvar-lichen-sclerosus/ This clinical trial is focused on studying a condition called vulvar lichen sclerosus (VLS), which affects the skin around the vulva, causing symptoms like itching and pain. The trial will test a new treatment called MC2-25 cream, which contains an active ingredient known as alanyl glutamine. The study will compare the effects of this cream to a similar cream that does not contain the active ingredient, referred to as the MC2-25 vehicle.

The purpose of the study is to explore how effective and safe the MC2-25 cream is for women diagnosed with vulvar lichen sclerosus. Participants in the study will be randomly assigned to one of two groups. One group will receive the MC2-25 cream, while the other group will receive the MC2-25 vehicle. Neither the participants nor the researchers will know which treatment each participant is receiving, a method known as “double-blind.” The study will last for 12 weeks, during which participants will apply the cream daily and keep a diary of their symptoms.

Throughout the study, researchers will monitor changes in symptoms such as itching and pain, using a scale called the Worst Itch Numeric Rating Score (WI-NRS) and the Worst Pain Numeric Rating Score (WP-NRS). The goal is to see if the MC2-25 cream provides significant relief compared to the MC2-25 vehicle. Participants will also complete a questionnaire called the Skindex-29 to assess the impact of the treatment on their quality of life. The study aims to provide valuable information on the potential benefits of the MC2-25 cream for managing vulvar lichen sclerosus.

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