Li-Fraumeni syndrome – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:18:24 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Li-Fraumeni syndrome – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of metformin for cancer prevention in adolescents and adults with Li-Fraumeni syndrome https://clinicaltrials.eu/trial/study-of-metformin-for-cancer-prevention-in-adolescents-and-adults-with-li-fraumeni-syndrome/ Wed, 29 Apr 2026 15:06:47 +0000 https://clinicaltrials.eu/trial/study-of-metformin-for-cancer-prevention-in-adolescents-and-adults-with-li-fraumeni-syndrome/ This study focuses on Li-Fraumeni syndrome (LFS), a rare inherited condition that increases the risk of developing various types of cancer. The research aims to determine if the medication metformin, commonly used to treat diabetes, can help prevent cancer in people with LFS when combined with regular cancer monitoring.

The study will evaluate two different forms of metformin: oral solution and film-coated tablets. Participants will receive a daily dose of up to 2000 milligrams of metformin for approximately 84 days. Some participants will receive metformin along with regular cancer surveillance, while others will only undergo cancer surveillance without receiving the medication.

During the study, participants will be monitored for any new cancer developments and their overall health status. The research team will track various factors, including the participants’ quality of life, emotional well-being, and any side effects from the treatment. They will also examine how factors like body weight and lifestyle choices might influence the treatment’s effectiveness.

]]>