Left ventricular failure – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 04:06:10 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Left ventricular failure – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of cardiac atrial stem cells injected into heart muscle for treating advanced heart failure in patients with prior heart attack and reduced heart function https://clinicaltrials.eu/trial/study-of-cardiac-atrial-stem-cells-injected-into-heart-muscle-for-treating-advanced-heart-failure-in-patients-with-prior-heart-attack-and-reduced-heart-function/ Wed, 29 Apr 2026 15:06:28 +0000 https://clinicaltrials.eu/trial/study-of-cardiac-atrial-stem-cells-injected-into-heart-muscle-for-treating-advanced-heart-failure-in-patients-with-prior-heart-attack-and-reduced-heart-function/ This study focuses on treating patients with heart failure, specifically those who have experienced a myocardial infarction (heart attack) and have reduced heart function. The treatment being investigated involves injecting special cells called cardiac atrial stem cells directly into the heart muscle. These cells are obtained from donor heart tissue and are being tested to help improve heart function in patients with damaged heart tissue.

The purpose of this research is to evaluate whether injecting these stem cells into the heart muscle is safe for patients with advanced heart failure. The treatment involves a surgical procedure where the cells are injected directly into specific areas of the heart that have been damaged by the previous heart attack. The study will monitor patients for any heart-related complications and track their overall health after receiving the treatment.

During the study, patients will receive the stem cell treatment along with their standard heart care. The research team will perform various tests to check heart function, including echocardiography (heart ultrasound) and magnetic resonance imaging (MRI) scans. Patients will be monitored regularly after the procedure to assess their recovery and any changes in their heart condition.

]]> Study on the Effects of Dobutamine and Levosimendan in Patients with Heart Failure and Reduced Left Ventricular Function https://clinicaltrials.eu/trial/study-on-the-effects-of-dobutamine-and-levosimendan-in-patients-with-heart-failure-and-reduced-left-ventricular-function/ Wed, 29 Apr 2026 15:02:34 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-dobutamine-and-levosimendan-in-patients-with-heart-failure-and-reduced-left-ventricular-function/ This clinical trial is focused on studying the effects of two medications, dobutamine and levosimendan, in the treatment of heart failure. Heart failure is a condition where the heart is unable to pump blood effectively, leading to symptoms like shortness of breath and fatigue. The study specifically looks at patients with a reduced ability of the heart’s left ventricle to pump blood, known as depressed left ventricular ejection fraction.

The purpose of the study is to compare how these two medications affect the heart and blood vessels. Participants will receive either dobutamine or levosimendan, both administered intravenously, meaning they are given directly into a vein. The study will observe changes in the pressure within the lungs’ blood vessels and the amount of blood the heart pumps. These observations will help understand how each medication works in the current treatment context for heart diseases.

Throughout the study, participants will be monitored for various health indicators, including heart function and overall well-being. The study will last for a period of time, during which participants will have regular check-ups to assess their heart’s performance and any side effects from the medications. The goal is to gather information that could improve treatment options for people with heart failure.

]]> Study on the Effects of CDR132L in Patients with Reduced Heart Function After a Heart Attack https://clinicaltrials.eu/trial/study-on-the-effects-of-cdr132l-in-patients-with-reduced-heart-function-after-a-heart-attack/ Wed, 29 Apr 2026 14:22:34 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-cdr132l-in-patients-with-reduced-heart-function-after-a-heart-attack/ This clinical trial is focused on studying the effects of a new treatment called CDR132L in patients who have experienced a heart attack, also known as a myocardial infarction. After a heart attack, some patients have a condition where the heart’s left side does not pump blood as well as it should, which is referred to as a reduced left ventricular ejection fraction (LVEF). This study aims to evaluate the safety and effectiveness of CDR132L in improving heart function in these patients.

The study involves three groups of participants. One group will receive a low dose of CDR132L, another group will receive a higher dose, and the third group will receive a placebo. The treatment is given through an intravenous infusion, which means it is administered directly into the bloodstream. Participants will receive three doses, each given 28 days apart. The study will monitor changes in heart function and overall health over a period of time to determine the impact of the treatment.

Throughout the study, participants will undergo various health assessments, including heart imaging tests and blood tests, to track their progress. The goal is to see if CDR132L can help improve heart function and reduce symptoms associated with heart failure after a heart attack. The study will also keep track of any side effects or health changes experienced by participants to ensure the treatment is safe.

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