Knee arthroplasty – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:32:15 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Knee arthroplasty – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Comparing Remifentanil, Propofol, Bupivacaine, Sufentanil, and Fentanyl for patients undergoing outpatient total knee and hip replacement surgery https://clinicaltrials.eu/trial/comparing-remifentanil-propofol-bupivacaine-sufentanil-and-fentanyl-for-patients-undergoing-outpatient-total-knee-and-hip-replacement-surgery/ Wed, 29 Apr 2026 15:09:26 +0000 https://clinicaltrials.eu/trial/comparing-remifentanil-propofol-bupivacaine-sufentanil-and-fentanyl-for-patients-undergoing-outpatient-total-knee-and-hip-replacement-surgery/ This study is designed to compare the effects of different types of anesthesia during Total Knee Arthroplasty and Total Hip Arthroplasty, which are surgical procedures used to replace a damaged knee or hip joint. The research aims to determine if General Anaesthesia, where a patient is completely asleep, or Spinal Anaesthesia, which numbs a specific part of the body, leads to a higher rate of successful discharge on the same day as the surgery. Participants will receive one of these two methods of anesthesia to undergo their joint replacement procedures.

The group receiving General Anaesthesia will be given remifentanil hydrochloride and propofol through an intravenous infusion, which is a method of delivering medication directly into a vein. The group receiving Spinal Anaesthesia will receive medications through intrathecal use, which means the medicine is injected into the fluid surrounding the spinal cord. The medications used for this method include bupivacaine hydrochloride, epinephrine, sufentanil citrate, or fentanyl citrate.

During the course of the study, researchers will observe the time it takes for patients to move from the start of anesthesia through different stages of recovery. Information will be gathered regarding the use of analgesics, which are pain-relieving medicines, and the levels of pain experienced after surgery. The study will also track the ability of patients to move around, such as walking, and will monitor any unwanted side effects or the need for blood transfusions to ensure patient safety and recovery quality.

]]> Study on Temporarily Stopping Duloxetine, Sertraline, and Paroxetine in Patients with Hip or Knee Osteoarthritis Undergoing Surgery https://clinicaltrials.eu/trial/study-on-temporarily-stopping-duloxetine-sertraline-and-paroxetine-in-patients-with-hip-or-knee-osteoarthritis-undergoing-surgery/ Wed, 29 Apr 2026 14:47:30 +0000 https://clinicaltrials.eu/trial/study-on-temporarily-stopping-duloxetine-sertraline-and-paroxetine-in-patients-with-hip-or-knee-osteoarthritis-undergoing-surgery/ This clinical trial is focused on patients with hip and knee osteoarthritis who are scheduled for hip or knee replacement surgery. The study is investigating the possibility of temporarily stopping certain medications known as serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) before surgery. These medications include duloxetine, sertraline hydrochloride, paroxetine hydrochloride, citalopram, and citalopram hydrobromide. The purpose of the study is to see if patients can safely stop taking these medications for a short time without experiencing withdrawal symptoms or a return of depression and anxiety.

Participants in the study will be asked to stop taking their SSRI or SNRI medication for a short period before their surgery. The study will monitor how well patients manage without their medication and whether they experience any symptoms of withdrawal or a return of their mental health conditions. The study will also look at how many patients are able to reduce their medication dose if they cannot stop completely. Patients will be assessed at different times: at the start of the study, two weeks later, the day before surgery, and two months after surgery.

The study aims to understand the effects of stopping these medications temporarily and to gather information on how many patients can successfully do so. This information could help improve care for patients undergoing hip or knee replacement surgery who are taking SSRIs or SNRIs. The study will run until 2026, with recruitment starting in 2024.

]]> Study on the Safety of Ibuprofen for Patients Experiencing Pain After Hip and Knee Replacement Surgery https://clinicaltrials.eu/trial/study-on-the-safety-of-ibuprofen-for-patients-experiencing-pain-after-hip-and-knee-replacement-surgery/ Wed, 29 Apr 2026 14:24:42 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-of-ibuprofen-for-patients-experiencing-pain-after-hip-and-knee-replacement-surgery/ This clinical trial is focused on understanding the safety of using ibuprofen after major orthopedic surgeries, specifically hip and knee replacements. Ibuprofen is a common medication used to relieve pain and reduce inflammation. The study will look at its effects on patients who have undergone these surgeries and are experiencing acute postoperative pain.

The purpose of the study is to assess both the helpful and potentially harmful effects of taking ibuprofen for eight days after surgery. Participants will be randomly assigned to receive either ibuprofen or an identical capsule that does not contain the active medication, known as a placebo. The study will monitor for any serious health issues, such as heart problems or bleeding, within 90 days after surgery. It will also track any side effects related to ibuprofen, like stomach discomfort or diarrhea, and compare them to side effects from other pain medications, such as nausea or constipation.

Throughout the study, participants will keep a diary of their symptoms and complete a health-related quality of life questionnaire. This will help researchers understand how ibuprofen affects recovery and overall well-being after surgery. The study aims to provide valuable information on the safe use of ibuprofen in managing pain after hip and knee surgeries.

]]> Study on Magnesium Sulfate and Ropivacaine for Pain Relief in Knee Replacement Surgery Patients https://clinicaltrials.eu/trial/study-on-magnesium-sulfate-and-ropivacaine-for-pain-relief-in-knee-replacement-surgery-patients/ Wed, 29 Apr 2026 14:23:06 +0000 https://clinicaltrials.eu/trial/study-on-magnesium-sulfate-and-ropivacaine-for-pain-relief-in-knee-replacement-surgery-patients/ This clinical trial is focused on studying the effects of magnesium sulfate in patients undergoing total knee replacement surgery. The trial aims to determine if magnesium sulfate can enhance the effectiveness of a nerve block, which is a type of anesthesia used to reduce pain during and after surgery. The nerve block is performed using ropivacaine hydrochloride, a local anesthetic that numbs the area around the knee. In this study, magnesium sulfate is used as an additional treatment to see if it can prolong the pain relief provided by the nerve block.

Participants in the study will receive an injection of either magnesium sulfate or a placebo along with ropivacaine hydrochloride during their knee surgery. The study will monitor how long it takes for patients to request additional pain relief after receiving the nerve block. This will help researchers understand if magnesium sulfate can effectively extend the duration of pain relief.

The purpose of this study is to evaluate the potential benefits of using magnesium sulfate as an adjuvant, or helper, to improve pain management in patients undergoing total knee replacement surgery. The trial is designed to provide valuable information on whether this combination can offer better pain control, which could lead to improved recovery experiences for patients undergoing this common surgical procedure.

]]>