Kearns-Sayre syndrome – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:30:38 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Kearns-Sayre syndrome – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effects of Calcium Folinate in Patients with Kearns-Sayre Syndrome and Cerebral Folate Deficiency https://clinicaltrials.eu/trial/study-on-the-effects-of-calcium-folinate-in-patients-with-kearns-sayre-syndrome-and-cerebral-folate-deficiency/ Wed, 29 Apr 2026 14:26:25 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-calcium-folinate-in-patients-with-kearns-sayre-syndrome-and-cerebral-folate-deficiency/ This clinical trial is focused on studying the effects of a treatment for two specific conditions: Kearns-Sayre syndrome and cerebral folate deficiency. The treatment being tested is called folinic acid, which is a form of vitamin B9. The purpose of the study is to evaluate how effective folinic acid is in improving the health outcomes of patients with these conditions compared to no treatment at all.

The study will involve participants taking folinic acid either by mouth or through an intravenous (IV) method. The trial will last for a period of up to 18 months, during which participants will have their health monitored at several points in time. This will help researchers understand any changes in the participants’ condition and how folinic acid might be helping. The study will also look at various health markers, such as brain volume and certain chemicals in the brain, using techniques like magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).

Participants in the study will be children and adolescents who have been diagnosed with Kearns-Sayre syndrome, a rare genetic disorder that affects the muscles and other parts of the body. The study aims to provide valuable insights into whether folinic acid can be a beneficial treatment option for these patients, potentially improving their quality of life and managing symptoms associated with their conditions.

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