Infectious pleural effusion – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:25:17 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Infectious pleural effusion – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Early Saline Pleural Irrigation for Patients with Complicated Pleural Infections https://clinicaltrials.eu/trial/early-saline-pleural-irrigation-for-patients-with-complicated-pleural-infections/ Tue, 02 Jun 2026 04:17:44 +0000 https://clinicaltrials.eu/trial/early-saline-pleural-irrigation-for-patients-with-complicated-pleural-infections/ This clinical trial is studying complicated pleural infections, which are serious infections in the space around the lungs. The purpose of the study is to compare an early pleural irrigation strategy, which means washing out the infected chest space with saline (salt water), with standard care. The study also uses usual infection treatment with antibiotics such as clindamycin, linezolid, vancomycin, cefepime, piperacillin/tazobactam, amoxicillin/clavulanic acid, cefotaxime, and metronidazole; in some cases, other treatments such as alteplase, urokinase, or dornase alfa may also be used to help clear fluid from the chest.

In this study, people are assigned to one of two treatment approaches. One group receives early pleural irrigation with saline along with standard treatment, while the other group receives standard care alone. Treatment is given during the hospital stay, and the patient is followed for about 30 days after treatment starts to see how the infection progresses and whether extra treatment is needed. The study is designed to see which approach works better for this type of chest infection.

]]> Study Comparing Dornase Alfa and Alteplase with Surgery for Treating Pleural Empyema in Patients https://clinicaltrials.eu/trial/study-comparing-dornase-alfa-and-alteplase-with-surgery-for-treating-pleural-empyema-in-patients/ Wed, 29 Apr 2026 14:28:00 +0000 https://clinicaltrials.eu/trial/study-comparing-dornase-alfa-and-alteplase-with-surgery-for-treating-pleural-empyema-in-patients/ This clinical trial is focused on studying the treatment of pleural empyema, a condition where pus gathers in the space between the lungs and the inner surface of the chest wall. The study will compare two different treatment approaches. One approach involves using medications called dornase alfa and alteplase, which are administered directly into the pleural space to help break down and clear the pus. The other approach is a surgical procedure known as VATS (Video-Assisted Thoracoscopic Surgery), which is a minimally invasive surgery used to remove the pus.

The purpose of the study is to determine whether the surgical procedure is more effective than the medication treatment in managing pleural empyema. Participants in the study will be randomly assigned to receive either the medication treatment or the surgical procedure. The study will last for a period of up to three weeks, during which the effects of the treatments will be monitored and compared.

Throughout the study, participants will receive regular medical assessments to ensure their safety and to evaluate the progress of their treatment. The findings from this study aim to provide valuable insights into the best treatment options for individuals suffering from pleural empyema.

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