Infection prophylaxis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 12:26:04 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Infection prophylaxis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of human normal immunoglobulin to prevent major infections in patients with hypogammaglobulinemia and autoimmune/rheumatic disease on B‑cell depletion therapy https://clinicaltrials.eu/trial/study-of-human-normal-immunoglobulin-to-prevent-major-infections-in-patients-with-hypogammaglobulinemia-and-autoimmune-rheumatic-disease-on-b-cell-depletion-therapy/ Wed, 13 May 2026 05:05:04 +0000 https://clinicaltrials.eu/trial/study-of-human-normal-immunoglobulin-to-prevent-major-infections-in-patients-with-hypogammaglobulinemia-and-autoimmune-rheumatic-disease-on-b-cell-depletion-therapy/ The trial looks at people who have low levels of antibodies (called hypogammaglobulinemia) and who also have conditions where the immune system attacks the body, such as autoimmune or rheumatic conditions. These patients often receive medicines that remove B cells (B-cell depletion therapy), which can further weaken the immune system and increase the risk of serious infections. The study tests an intravenous solution of Panzyga, which contains human normal immunoglobulin, compared with a simple salt solution (sodium chloride) used as a placebo.

The aim is to see if adding Panzyga can lower the chance of a major infection or death in this vulnerable group. Participants will receive the assigned infusion once every few weeks for several months, and they will be checked regularly by doctors for any signs of infection, side effects, or changes in health. The study is set up so that neither the participants nor the doctors know which infusion is being given, to keep the comparison fair.

Throughout the trial, any infection that occurs will be recorded, and an independent group of experts will decide whether it meets the definition of a major infection. Safety will also be monitored by looking at reported side effects and routine lab tests. The information gathered will help determine whether the treatment is safe and effective for preventing serious infections in people with weak immune systems due to their underlying disease and therapy.

]]> Study of the distribution of cefazolin in the chest area of children undergoing heart surgery to prevent infection. https://clinicaltrials.eu/trial/study-of-the-distribution-of-cefazolin-in-the-mediastinum-of-children-following-cardiac-surgery-to-prevent-infection/ Wed, 29 Apr 2026 15:09:51 +0000 https://clinicaltrials.eu/trial/study-of-the-distribution-of-cefazolin-in-the-mediastinum-of-children-following-cardiac-surgery-to-prevent-infection/ This study aims to describe how the antibiotic cefazolin moves through the mediastinum, which is the area in the middle of the chest between the lungs, in children after heart surgery. The research focuses on infection prophylaxis, which is a way to prevent infections from occurring before they start. During the study, cefazolin is given through intravenous administration, meaning it is delivered directly into a vein.

The process involves using microdialysis, a method used to monitor the levels of a substance in the body’s tissues. Participants will have their levels monitored to see how the medication travels from the blood into the chest area. Researchers will also monitor signs of inflammation, such as CRP, which is a protein in the blood that increases when there is irritation or infection in the body, and watch for any signs of mediastinitis, an infection in the middle of the chest.

]]> Study on Preventing Infections in ICU Patients with Interferon Gamma and Sodium Chloride https://clinicaltrials.eu/trial/study-on-preventing-infections-in-icu-patients-with-interferon-gamma-and-sodium-chloride/ Wed, 29 Apr 2026 15:04:40 +0000 https://clinicaltrials.eu/trial/study-on-preventing-infections-in-icu-patients-with-interferon-gamma-and-sodium-chloride/ This clinical trial is focused on patients who have developed sustained immunosuppression while being treated in the intensive care unit (ICU). This condition means that the body’s immune system is weakened and less able to fight off infections. The study is testing a treatment called recombinant human interferon gamma 1b, which is a type of protein that can help boost the immune system. This treatment is being compared to a placebo to see if it can reduce the number of additional infections that patients might get while in the ICU.

The purpose of the study is to find out if using recombinant human interferon gamma 1b can lower the chances of getting new infections over a period of three months. Patients in the study will receive the treatment through a subcutaneous injection, which means it is given under the skin. The study will last for about three months, during which the health of the patients will be closely monitored to see if the treatment is effective and safe.

In addition to looking at the number of new infections, the study will also track other important outcomes, such as the overall survival of patients in the ICU, the length of their stay in the hospital, and any side effects they might experience. The study aims to provide valuable information on whether this treatment can help improve the health and recovery of patients with sustained immunosuppression in the ICU.

]]> Study of cefuroxime and metronidazole to prevent infections after Whipple’s procedure in patients with high risk of bile contamination https://clinicaltrials.eu/trial/study-on-metronidazole-and-cefuroxime-to-prevent-infections-after-whipples-procedure-in-patients-at-high-risk-for-contaminated-bile/ Wed, 29 Apr 2026 14:28:38 +0000 https://clinicaltrials.eu/trial/study-on-metronidazole-and-cefuroxime-to-prevent-infections-after-whipples-procedure-in-patients-at-high-risk-for-contaminated-bile/ This clinical trial focuses on patients undergoing pancreatoduodenectomy (also known as Whipple’s procedure), which is a major surgery to remove parts of the pancreas and surrounding organs. The study specifically looks at patients who have a higher risk of infection due to having had bile drainage before surgery or having a tumor near the pancreas. The purpose is to evaluate whether giving preventive antibiotics can reduce the occurrence of serious infections after surgery.

The study will use two antibiotics: metronidazole and cefuroxime, which are medications commonly used to prevent and treat infections. These medications will be given through an infusion (a drip into the vein). The maximum daily dose of metronidazole will be 1500 mg, and for cefuroxime, it will be 4500 mg. The treatment period will last up to 5 days.

During the study, doctors will monitor patients for signs of infection, particularly focusing on infections that develop deep inside the surgical area. They will also track other complications that might occur after surgery, including problems with wound healing, bleeding, or delayed stomach emptying. The study will help determine the most effective way to prevent infections in patients having this type of surgery.

]]> Study on Infection Prevention in Joint Replacement Surgery Using Povidone, Chlorhexidine, and Vancomycin for Adult Patients https://clinicaltrials.eu/trial/study-on-infection-prevention-in-joint-replacement-surgery-using-povidone-chlorhexidine-and-vancomycin-for-adult-patients/ Wed, 29 Apr 2026 14:23:21 +0000 https://clinicaltrials.eu/trial/study-on-infection-prevention-in-joint-replacement-surgery-using-povidone-chlorhexidine-and-vancomycin-for-adult-patients/ This clinical trial is focused on patients undergoing total joint replacement (TJR) surgery, which involves replacing a damaged joint, such as a hip or knee, with an artificial one. The study aims to explore new treatments to prevent infections after these surgeries. Infections can be a serious complication, sometimes requiring additional surgery to address them. The trial will compare different solutions used during surgery to see if they can reduce the risk of infection within 12 months after the procedure.

Participants in the study will receive one of several treatments. One group will receive a solution containing povidone, a type of antiseptic, while another group will receive a solution with chlorhexidine, which is also used to kill bacteria. There is also a group that will receive vancomycin, an antibiotic, applied locally during surgery. These treatments will be compared to a standard saline solution, which is a simple saltwater solution commonly used in medical settings. The purpose is to determine if these treatments can lower the chances of needing another surgery due to infection.

The study will follow participants for up to 12 months after their surgery to monitor for any infections that might require reoperation. By comparing the outcomes of the different treatment groups, researchers hope to find more effective ways to prevent infections in patients undergoing TJR surgery. This could lead to improved recovery and fewer complications for future patients undergoing similar procedures.

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