Infant sedation – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:36:38 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Infant sedation – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Sedation Effects of Dexmedetomidine vs. Midazolam in Mechanically Ventilated Preterm Infants https://clinicaltrials.eu/trial/study-on-sedation-effects-of-dexmedetomidine-vs-midazolam-in-mechanically-ventilated-preterm-infants/ Wed, 29 Apr 2026 15:00:15 +0000 https://clinicaltrials.eu/trial/study-on-sedation-effects-of-dexmedetomidine-vs-midazolam-in-mechanically-ventilated-preterm-infants/ This clinical trial is focused on studying the effects of two different sedative medications, dexmedetomidine and midazolam, on very preterm infants who require mechanical ventilation. Very preterm infants are babies born before 32 weeks of pregnancy and may need help with breathing through a machine. The purpose of the study is to compare how these medications affect the time it takes for these infants to be safely removed from the ventilator, a process known as extubation.

During the study, infants will receive either dexmedetomidine or midazolam as part of their sedation while on mechanical ventilation. The study will observe how long it takes for the infants to be extubated after stopping the sedative medication. Additionally, researchers will monitor other factors such as the need for additional pain relief, the time it takes for the infants to reach a comfortable state, and any potential side effects related to heart rate, blood pressure, or breathing.

The study aims to provide valuable information on which sedative might be more effective and safer for very preterm infants in this critical care setting. The trial is expected to run until December 2028, with recruitment starting in September 2024. This research could help improve care for very preterm infants who need mechanical ventilation by identifying the best sedation practices.

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