Hypoxic ischaemic encephalopathy neonatal – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 04:11:25 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Hypoxic ischaemic encephalopathy neonatal – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of Autologous Cord Blood Stem Cells Treatment for Newborns with Hypoxic-Ischemic Encephalopathy https://clinicaltrials.eu/trial/study-on-the-safety-and-feasibility-of-using-autologous-cord-blood-stem-cells-for-treating-newborns-with-hypoxic-ischemic-encephalopathy/ Wed, 29 Apr 2026 14:59:39 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-feasibility-of-using-autologous-cord-blood-stem-cells-for-treating-newborns-with-hypoxic-ischemic-encephalopathy/ This study focuses on treating newborns with neonatal hypoxic-ischemic encephalopathy, a serious condition where the baby’s brain doesn’t receive enough oxygen and blood around the time of birth. The treatment being tested uses autologous cord blood stem cells, which are special cells collected from the baby’s own umbilical cord blood.

The study aims to determine if using these stem cells is safe and possible as a treatment option for newborns with brain injury caused by oxygen deprivation. The treatment involves giving the processed stem cells back to the baby through intravenous infusion, which means the cells are delivered directly into the bloodstream.

During the study, babies will receive their own cord blood cells that have been specially prepared as a medical treatment. The treatment is given alongside standard cooling therapy (therapeutic hypothermia) that these babies typically receive. Doctors will monitor the children’s development and check for any effects of the treatment for up to two years after the procedure.

]]> Study on Sildenafil and Hypothermia for Newborns with Hypoxic-Ischemic Encephalopathy https://clinicaltrials.eu/trial/study-on-sildenafil-and-hypothermia-for-newborns-with-hypoxic-ischemic-encephalopathy/ Wed, 29 Apr 2026 14:23:14 +0000 https://clinicaltrials.eu/trial/study-on-sildenafil-and-hypothermia-for-newborns-with-hypoxic-ischemic-encephalopathy/ This clinical trial is focused on studying a condition known as hypoxic-ischemic encephalopathy in newborns. This condition occurs when a baby’s brain doesn’t receive enough oxygen and blood, which can lead to brain damage. The study will explore the effects of a treatment combining sildenafil and controlled cooling, also known as hypothermia, to see if it can improve survival without brain injuries. Sildenafil is a medication that is being tested in this study in the form of a solution for injection.

The purpose of the study is to determine if the combination of sildenafil and hypothermia is more effective than hypothermia alone. The study will be conducted in two steps. In the first step, researchers will examine how the body processes sildenafil in newborns with the condition. In the second step, the study will compare the outcomes of newborns receiving the combination treatment to those receiving a placebo, focusing on survival without brain lesions as seen on an MRI scan at the time of hospital discharge.

Throughout the study, researchers will monitor various aspects of the newborns’ health, including brain activity and heart function, to assess both the potential benefits and safety of the treatment. The study aims to provide valuable insights into whether this treatment approach can help improve outcomes for newborns affected by hypoxic-ischemic encephalopathy.

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