Hypoxia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:14:43 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Hypoxia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Deferoxamine to Improve Hypoxia Response in Type 1 Diabetes Patients https://clinicaltrials.eu/trial/study-on-deferoxamine-to-improve-hypoxia-response-in-type-1-diabetes-patients/ Wed, 29 Apr 2026 15:03:26 +0000 https://clinicaltrials.eu/trial/study-on-deferoxamine-to-improve-hypoxia-response-in-type-1-diabetes-patients/ This clinical trial is focused on studying the effects of a medication called Desferal on people with Type 1 Diabetes. Type 1 Diabetes is a condition where the body does not produce insulin, a hormone needed to control blood sugar levels. The study aims to see if Desferal can help improve how patients with this condition respond to low oxygen levels, a situation known as hypoxia.

Participants in the study will receive Desferal, which is given as an injection or infusion, meaning it is administered directly into the bloodstream. The study is designed to compare the effects of Desferal with a placebo, which is a substance with no active medication. This comparison helps researchers understand the true effects of Desferal. The study will follow a cross-over design, meaning participants will receive both Desferal and the placebo at different times during the study.

The main goal of the study is to determine if Desferal can improve the body’s response to hypoxia in patients with Type 1 Diabetes. This involves monitoring changes in certain cells and substances in the blood that are related to blood vessel growth and oxygen levels. The study will also look at various heart and lung functions to see how they are affected by the treatment. The trial is expected to continue until the end of 2026.

]]> Oxygen Therapy to Prevent Breathing Problems After Non-Cardiac Surgery in Patients at Risk for Postoperative Complications https://clinicaltrials.eu/trial/oxygen-therapy-to-prevent-breathing-problems-after-non-cardiac-surgery-in-patients-at-risk-for-postoperative-complications/ Wed, 29 Apr 2026 14:58:41 +0000 https://clinicaltrials.eu/trial/oxygen-therapy-to-prevent-breathing-problems-after-non-cardiac-surgery-in-patients-at-risk-for-postoperative-complications/ This clinical trial is focused on patients who are at risk for complications after undergoing non-cardiac surgeries, such as general or urology surgeries. The study is investigating the use of a treatment involving the administration of oxygen through a nasal cannula at a rate of 3 liters per minute. The aim is to see if this oxygen supply can help reduce temporary drops in blood oxygen levels, known as desaturation, which can occur after surgery.

The trial is called the AIOLOS trial and will compare two groups of patients. One group will receive the oxygen treatment, while the other group will receive the standard care that is typically provided after surgery. The main goal is to observe the average time that patients’ blood oxygen levels fall below 90% during the first two days after their surgery. This will be measured using a device called a pulse oximeter, which is a simple tool that clips onto a finger to monitor oxygen levels in the blood.

In addition to monitoring oxygen levels, the study will also look at other factors such as the quality of recovery on the first day after surgery, the occurrence of delirium, and any surgical site infections within 30 days. The trial is expected to start recruiting participants in October 2024 and aims to conclude by November 2025. The results of this study could help improve care for patients recovering from surgery by providing insights into the benefits of supplemental oxygen therapy.

]]> A Study of High-Concentration Oxygen Treatment in Patients with Heart Failure, Pulmonary Hypertension, and Coronary Microvascular Dysfunction https://clinicaltrials.eu/trial/study-on-the-effects-of-oxygen-on-blood-flow-in-patients-with-pulmonary-hypertension-coronary-microvascular-dysfunction-hypoxia-or-heart-failure/ Wed, 29 Apr 2026 14:58:24 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-oxygen-on-blood-flow-in-patients-with-pulmonary-hypertension-coronary-microvascular-dysfunction-hypoxia-or-heart-failure/ This study focuses on several heart and lung conditions including Pulmonary Hypertension, Coronary Microvascular Dysfunction, Heart Failure, and conditions involving low oxygen levels in the body (Hypoxia). The study aims to understand how high-concentration oxygen affects blood flow and blood vessel resistance in different parts of the body, particularly in the heart and lungs.

The treatment being studied is Conoxia, which is a medical-grade oxygen given in its liquid, extremely cold form (cryogenic). This pure oxygen will be administered to participants to examine its effects on blood circulation. The study will measure how the heart pumps blood and how blood vessels respond to this oxygen treatment.

During the study, measurements will be taken at different time points to see how quickly the body responds to the oxygen treatment. The study will look at blood flow changes in various parts of the body, including the heart’s small blood vessels and the blood vessels in the lungs. These measurements will help understand how oxygen treatment affects blood circulation throughout the body.

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