Hypothyroidism – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:23:54 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Hypothyroidism – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Effect of levothyroxine on kidney function in patients at risk of hypothyroidism after partial thyroid surgery https://clinicaltrials.eu/trial/effect-of-levothyroxine-on-kidney-function-in-patients-at-risk-of-hypothyroidism-after-partial-thyroid-surgery/ Wed, 29 Apr 2026 15:09:17 +0000 https://clinicaltrials.eu/trial/effect-of-levothyroxine-on-kidney-function-in-patients-at-risk-of-hypothyroidism-after-partial-thyroid-surgery/ This study focuses on individuals at risk of developing Hypothyroidism, a condition where the thyroid gland does not produce enough hormones to meet the body’s needs, following a Hemithyroidectomy, which is the surgical removal of half of the thyroid gland. The research aims to evaluate whether starting treatment with Levothyroxine early after surgery affects kidney health and overall well-being. Potential risks being investigated include Incident Kidney Dysfunction, which refers to a sudden decline in how well the kidneys work, and Chronic Kidney Disease, a long-term condition where the kidneys cannot filter blood as well as they should.

Participants in the study may receive different doses of Levothyroxine Sodium or a placebo. During the study, monitoring will involve checking levels of hormones such as TSH, T4, and T3 in the blood to see how the body is responding to the treatment. Other factors being observed include eGFR, which is a measurement used to check how well the kidneys are filtering waste from the blood, as well as changes in body weight and BMI. The study will follow participants over several months to observe these changes and assess their health-related quality of life.

]]> Study on Levothyroxine and Liothyronine for Patients with Autoimmune Hypothyroidism and Persistent Tiredness https://clinicaltrials.eu/trial/study-on-levothyroxine-and-liothyronine-for-patients-with-autoimmune-hypothyroidism-and-persistent-tiredness/ Wed, 29 Apr 2026 15:02:12 +0000 https://clinicaltrials.eu/trial/study-on-levothyroxine-and-liothyronine-for-patients-with-autoimmune-hypothyroidism-and-persistent-tiredness/ This clinical trial is focused on studying the effects of a combination therapy for patients with autoimmune hypothyroidism, a condition where the thyroid gland does not produce enough hormones, leading to symptoms like tiredness. The study will compare the effects of a combination of two medications, levothyroxine and liothyronine, against the use of levothyroxine alone. Levothyroxine is a synthetic form of the thyroid hormone thyroxine, while liothyronine is a synthetic form of the hormone triiodothyronine. The trial will also include a group receiving a placebo, which looks like the medication but contains no active ingredients.

The purpose of the study is to investigate whether the combination of levothyroxine and liothyronine can reduce tiredness more effectively than levothyroxine alone in patients who continue to feel tired despite treatment. The study will last for one year, during which participants will receive either the combination therapy, levothyroxine alone, or a placebo. Researchers will monitor changes in tiredness and other thyroid-related symptoms, as well as overall quality of life. The study will also explore if certain genetic variations in participants affect the treatment outcomes.

Participants will be asked to take the medication orally and will have regular check-ups to assess their symptoms and any side effects. The trial aims to provide insights into whether the combination therapy offers a better treatment option for those with persistent symptoms of autoimmune hypothyroidism. The findings could help improve treatment strategies and enhance the quality of life for patients with this condition.

]]> Study on Levothyroxine and Sildenafil for Improving Erectile Function in Patients with Subclinical Hypothyroidism and Erectile Dysfunction https://clinicaltrials.eu/trial/study-on-levothyroxine-and-sildenafil-for-improving-erectile-function-in-patients-with-subclinical-hypothyroidism-and-erectile-dysfunction/ Wed, 29 Apr 2026 14:58:53 +0000 https://clinicaltrials.eu/trial/study-on-levothyroxine-and-sildenafil-for-improving-erectile-function-in-patients-with-subclinical-hypothyroidism-and-erectile-dysfunction/ This clinical trial is focused on studying the effects of two medications, levothyroxine and sildenafil, on individuals with hypothyroidism and erectile dysfunction. Hypothyroidism is a condition where the thyroid gland does not produce enough hormones, which can affect various bodily functions, including sexual health. Erectile dysfunction is the inability to achieve or maintain an erection suitable for sexual activity. Levothyroxine is a medication used to treat hypothyroidism by replacing the hormone that the thyroid gland is unable to produce. Sildenafil is commonly used to treat erectile dysfunction by increasing blood flow to the penis.

The purpose of this study is to assess how levothyroxine, when adjusted for weight and baseline thyroid-stimulating hormone (TSH) levels, impacts sexual activity in patients with subclinical hypothyroidism and erectile dysfunction. Participants will be randomly assigned to receive either levothyroxine, sildenafil, or a placebo. The study will last for three months, during which participants will take the medication orally. Throughout the study, participants will complete questionnaires to evaluate changes in their erectile function and overall satisfaction with the treatment.

Participants will be monitored at the beginning of the study and again after three months to track any changes in their condition. The study aims to provide insights into the effectiveness of levothyroxine in improving erectile function in patients with subclinical hypothyroidism. This research could potentially lead to better treatment options for individuals experiencing these conditions.

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