Hypocalcaemia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 18 Jun 2026 04:07:56 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Hypocalcaemia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of encaleret compared to standard care in patients with autosomal dominant hypocalcemia type 1 https://clinicaltrials.eu/trial/study-of-encaleret-compared-to-standard-care-in-patients-with-autosomal-dominant-hypocalcemia-type-1/ Wed, 29 Apr 2026 15:08:25 +0000 https://clinicaltrials.eu/trial/study-of-encaleret-compared-to-standard-care-in-patients-with-autosomal-dominant-hypocalcemia-type-1/ This clinical study is looking at a rare genetic condition called Autosomal Dominant Hypocalcemia Type 1, which is caused by changes in a specific gene that affects calcium levels in the body. People with this condition typically have low calcium levels in their blood and high calcium levels in their urine, which can cause various symptoms such as muscle cramps, muscle spasms, tingling sensations, headaches, kidney stones, and seizures. The study will test a medication called encaleret sulfate, also known by the code name CLTX-305, and compare it to standard of care treatment. Standard of care treatment may include medications such as calcium carbonate, calcium acetate, alfacalcidol, calcitriol, and colecalciferol, which are typically used to manage calcium levels in patients with this condition. The purpose of the study is to find out if encaleret is more effective than standard of care treatment in normalizing calcium levels in the blood and reducing calcium loss through urine.

Participants in this study will be randomly assigned to receive either encaleret or to continue with their standard of care treatment. The study is divided into several periods where treatment doses may be adjusted to find the best dose for each person. During the study, participants will have regular visits where doctors will check calcium levels in blood and urine, measure parathyroid hormone levels (a hormone that helps control calcium), and monitor other important body substances like phosphate and magnesium. Blood tests, urine tests, heart monitoring using electrocardiogram, kidney ultrasound examinations, and questionnaires about quality of life will be performed throughout the study. The study will last up to 54 months, and participants will be closely monitored for any side effects or changes in their condition.

The main goal is to determine how many participants achieve normal calcium levels in their blood and reduced calcium levels in their urine with each treatment approach. The study will also look at whether parathyroid hormone levels improve, how participants feel in their daily lives using health surveys, changes in kidney health, and the overall safety of the treatments. Doctors will track any unwanted effects, changes in vital signs, and the need for additional calcium or vitamin D supplements during the study. For those receiving encaleret, blood samples will be taken to measure medication levels in the body to ensure the drug is working properly.

]]> Study on Preventing Low Calcium Levels After Thyroid Surgery with Preoperative Cholecalciferol Supplementation for Patients Undergoing Total Thyroidectomy https://clinicaltrials.eu/trial/study-on-preventing-low-calcium-levels-after-thyroid-surgery-with-preoperative-cholecalciferol-supplementation-for-patients-undergoing-total-thyroidectomy/ Wed, 29 Apr 2026 14:23:00 +0000 https://clinicaltrials.eu/trial/study-on-preventing-low-calcium-levels-after-thyroid-surgery-with-preoperative-cholecalciferol-supplementation-for-patients-undergoing-total-thyroidectomy/ This clinical trial focuses on the condition known as hypocalcemia, which can occur after a surgical procedure called thyroidectomy. A thyroidectomy is a common surgery where the thyroid gland is removed. After this surgery, some patients may experience low levels of calcium in their blood, known as hypocalcemia, which can cause discomfort and require longer hospital stays. The study is investigating whether taking a supplement called cholecalciferol, which is a form of vitamin D, before the surgery can help reduce the chances of developing hypocalcemia afterward.

The treatment being studied is an oral solution called UVEDOSE 100,000 UI, which contains cholecalciferol. Participants in the study will receive this supplement before their thyroidectomy to see if it helps their bodies respond better to the changes in calcium levels after the surgery. The study aims to assess the effect of this pre-operative supplementation on the occurrence of hypocalcemia following the surgery.

Throughout the study, participants will be monitored for signs of hypocalcemia, such as tingling in the fingers or around the mouth, and their calcium levels will be checked. The study will also look at how long participants stay in the hospital, any side effects they experience, and whether they need additional treatments for low calcium levels. The goal is to determine if pre-operative cholecalciferol supplementation can improve recovery and reduce complications after a thyroidectomy.

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