Hormonal contraception – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 04:14:48 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Hormonal contraception – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 A study on ovulation inhibition with norelgestromin patch after missed applications in women who need birth control https://clinicaltrials.eu/trial/a-study-on-ovulation-inhibition-with-norelgestromin-patch-after-missed-applications-in-women-who-need-birth-control/ Wed, 29 Apr 2026 15:07:56 +0000 https://clinicaltrials.eu/trial/a-study-on-ovulation-inhibition-with-norelgestromin-patch-after-missed-applications-in-women-who-need-birth-control/ This study is looking at how well a contraceptive transdermal patch called MR-130A-01 works to prevent ovulation when it is not applied exactly as it should be. The patch contains a substance called norelgestromin, which is a type of synthetic progesterone that helps prevent pregnancy by stopping the release of eggs from the ovaries. The study is being done in healthy women who can have children to see if the patch still prevents ovulation even when there are intentional mistakes in how it is applied, such as delays of 24 hours or 48 hours in putting on a new patch.

The purpose of the study is to find out whether the patch continues to prevent ovulation despite these intentional application errors. Participants will use the patch for 84 days, which is about 12 weeks. During this time, they will follow different application schedules that include regular use of the patch, as well as cycles where patches are applied 24 hours late or 48 hours late on purpose. Throughout the study, participants will have regular examinations using transvaginal ultrasound, which is a procedure that uses sound waves to create images of the ovaries and uterus. Blood samples will also be collected to measure hormone levels such as progesterone, estradiol, and luteinizing hormone, which help determine if ovulation has occurred. The study will also check the levels of the medication in the blood and monitor how well the patch sticks to the skin.

The study will track whether ovulation happens during the different application schedules by looking at specific scores and measurements from the ultrasound images and hormone levels. Participants will also be asked to record any bleeding or spotting they experience, and the patch application site will be checked for any skin reactions. The overall safety of the patch will be monitored by recording any unwanted effects that occur during the study. Participants must agree to use non-hormonal methods of birth control, such as condoms or a diaphragm, during the study to prevent pregnancy.

]]> Study on the Effects of Hormonal Contraceptives on the Brain: Comparing Drospirenone and Estetrol with Ethinylestradiol and Levonorgestrel in Women Using Contraception https://clinicaltrials.eu/trial/study-on-the-effects-of-hormonal-contraceptives-on-the-brain-comparing-drospirenone-and-estetrol-with-ethinylestradiol-and-levonorgestrel-in-women-using-contraception/ Wed, 29 Apr 2026 15:05:33 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-hormonal-contraceptives-on-the-brain-comparing-drospirenone-and-estetrol-with-ethinylestradiol-and-levonorgestrel-in-women-using-contraception/ This clinical trial is focused on studying the effects of hormonal contraceptives on the brain. The study involves two types of combined oral contraceptives: one containing estetrol and drospirenone, and the other containing ethinylestradiol and levonorgestrel. These medications are commonly used for contraception, which is the prevention of pregnancy.

The purpose of the study is to determine if these contraceptives have different effects on the brain’s structure and function. Participants will be randomly assigned to take one of the two contraceptives or a placebo. The study will observe changes in the brain over time, focusing on areas such as grey matter, which is involved in processing information, and white matter, which connects different parts of the brain. The study will also look at how the brain responds when processing emotions.

Participants will be involved in the study for up to 12 months. During this time, they will undergo various assessments to monitor changes in their brain and overall well-being. The study will also evaluate changes in mood and quality of life. This research aims to provide a better understanding of how hormonal contraceptives might influence brain health and emotional well-being.

]]> Study on Ovulation Inhibition with Levonorgestrel Tablets for Contraception in Women with Intentional Intake Errors https://clinicaltrials.eu/trial/study-on-ovulation-inhibition-with-levonorgestrel-tablets-for-contraception-in-women-with-intentional-intake-errors/ Wed, 29 Apr 2026 15:05:14 +0000 https://clinicaltrials.eu/trial/study-on-ovulation-inhibition-with-levonorgestrel-tablets-for-contraception-in-women-with-intentional-intake-errors/ This clinical trial is focused on studying the effects of a medication called Levonorgestrel, which is used for contraception. The study aims to understand how well this medication can prevent ovulation, which is the release of an egg from the ovary, even when there are intentional delays in taking the tablet. The trial involves taking Levonorgestrel tablets continuously over three 28-day cycles.

The purpose of the study is to investigate if the prevention of ovulation is maintained despite scheduled delays in taking the medication. Participants will take the Levonorgestrel tablet daily, and the study will observe how effective the medication is in preventing ovulation during this period. The trial is designed to simulate real-life scenarios where a person might forget to take their contraceptive pill on time.

Throughout the study, participants will be monitored to see if ovulation occurs, which is determined by specific hormone levels in the body. The trial will help to provide more information on the reliability of Levonorgestrel as a contraceptive method, even when there are occasional delays in taking the pill. This research is important for understanding how to improve contraceptive options and ensure their effectiveness in everyday use.

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