Hernia repair – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:20:40 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Hernia repair – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 A Study of Botulinum Toxin Type A for Preparing the Abdominal Wall Before Surgery in Patients with Large Complex Hernias https://clinicaltrials.eu/trial/a-study-of-botulinum-toxin-type-a-for-preparing-the-abdominal-wall-before-surgery-in-patients-with-large-complex-hernias/ Thu, 30 Apr 2026 13:08:19 +0000 https://clinicaltrials.eu/trial/a-study-of-botulinum-toxin-type-a-for-preparing-the-abdominal-wall-before-surgery-in-patients-with-large-complex-hernias/ This study is looking at a condition where people have a large hernia in the abdominal wall, which is an opening or weakness in the muscles of the belly that allows tissue or organs to push through. In this case, the hernia is wide, the muscles on the side of the belly have been pulled back for a long time, and the organs inside the hernia cannot be pushed back into place easily. The treatment being studied is Botulinum Toxin Type A, which is a substance that can temporarily relax muscles. This medication will be given as an injection into the muscles of the abdominal wall before surgery to help prepare the area for repair.

The purpose of the study is to see if injecting Botulinum Toxin Type A into the side muscles of the abdominal wall causes changes in certain measurements that doctors use to predict whether additional surgical techniques will be needed to close the hernia. These measurements include the relationship between the width of certain belly muscles and the size of the hernia opening, the distance between specific points in the belly area seen on scans, the width of the hernia itself, the size of the side muscles, and the volume of the abdominal cavity. Doctors want to know if this injection helps improve these measurements before surgery.

During the study, patients will receive injections of Botulinum Toxin Type A into their abdominal wall muscles. Measurements will be taken using imaging scans before and after the injections to see what changes occur. The study will also look at how much of the sac containing the hernia needs to be used during surgery to close the layers of the abdominal wall, both in the back layer and the front layer. This information will help doctors understand if the toxin injections are helpful in preparing patients for hernia repair surgery.

]]> Study on the Effect of Levobupivacaine in Reducing Chronic Pain After Open Inguinal Hernia Repair in Patients https://clinicaltrials.eu/trial/study-on-the-effect-of-levobupivacaine-in-reducing-chronic-pain-after-open-inguinal-hernia-repair-in-patients/ Wed, 29 Apr 2026 15:00:46 +0000 https://clinicaltrials.eu/trial/study-on-the-effect-of-levobupivacaine-in-reducing-chronic-pain-after-open-inguinal-hernia-repair-in-patients/ This clinical trial is focused on studying chronic postsurgical pain that can occur after undergoing an open inguinal hernia mesh repair. The treatment being investigated is a technique called the transversus abdominis plane (TAP) block, which involves using a local anesthetic named Levobupivacaine. This anesthetic is administered through a local injection to help manage pain. The purpose of the study is to compare the effects of administering the TAP block before the surgical incision (preincisional) versus after the surgical incision (postincisional) on the development of chronic pain following the surgery.

Participants in the study will undergo the open inguinal hernia mesh repair procedure, which is a common surgery to fix hernias in the groin area. The study will observe the patients for a period of three months after their surgery to assess the incidence of chronic pain. The goal is to determine if the timing of the TAP block can help prevent chronic pain and reduce the need for long-term use of pain-relief medications.

This study aims to provide valuable insights into pain management strategies for patients undergoing this type of hernia repair, potentially improving recovery experiences and outcomes. By understanding the impact of the TAP block’s timing, healthcare providers can better tailor pain management approaches to enhance patient comfort and reduce the risk of chronic pain after surgery.

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