HER2 positive colorectal cancer – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:17:51 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png HER2 positive colorectal cancer – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of zanidatamab in adult patients with HER2-positive solid tumors (endometrial, colorectal, head & neck, sarcoma) or HER2-mutant non-small cell lung cancer https://clinicaltrials.eu/trial/study-of-zanidatamab-in-adults-with-her2-positive-solid-tumors-including-endometrial-colorectal-head-and-neck-cancers-sarcoma-or-her2-mutant-non-small-cell-lung-cancer/ Thu, 30 Apr 2026 13:07:57 +0000 https://clinicaltrials.eu/trial/study-of-zanidatamab-in-adults-with-her2-positive-solid-tumors-including-endometrial-colorectal-head-and-neck-cancers-sarcoma-or-her2-mutant-non-small-cell-lung-cancer/ This clinical trial focuses on treating patients with various types of solid tumors that have specific characteristics related to the HER2 gene. The study includes several types of cancer: endometrial cancer, colorectal cancer, head and neck cancer, non-small cell lung cancer, and sarcoma. These cancers must either show high levels of HER2 protein or have mutations in the HER2 gene.

The study uses a medication called zanidatamab (also known as JZP598), which is given through an intravenous infusion. This medicine is a powder that is first made into a concentrated solution before being given to patients. The maximum daily dose that can be given is 2400 milligrams, and treatment may continue for up to three years.

The main goal of this research is to determine how well zanidatamab works in treating these different types of cancer. The study will look at whether tumors respond to the treatment by shrinking or disappearing. Doctors will monitor patients regularly using scans to check how the tumors are responding to the treatment and to watch for any side effects that may occur.

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