Group B streptococcus neonatal sepsis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:28:23 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Group B streptococcus neonatal sepsis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Safety and Immune Response of GBS-NN/NN2 and Tdap Vaccines in Preventing Group B Strep Infection in Healthy Women Aged 18-49 https://clinicaltrials.eu/trial/study-on-the-safety-and-immune-response-of-gbs-nn-nn2-and-tdap-vaccines-in-preventing-group-b-strep-infection-in-healthy-women-aged-18-49/ Wed, 29 Apr 2026 15:05:45 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-immune-response-of-gbs-nn-nn2-and-tdap-vaccines-in-preventing-group-b-strep-infection-in-healthy-women-aged-18-49/ This clinical trial is focused on studying the prevention of Group B streptococcus infection, a type of bacterial infection that can be serious. The study involves two vaccines: the GBS-NN/NN2 vaccine and the Tdap vaccine. The GBS-NN/NN2 vaccine is designed to protect against Group B streptococcus, while the Tdap vaccine is used to protect against three diseases: diphtheria, tetanus, and pertussis (whooping cough). The trial will also use a substance called 0.9% sodium chloride, which is a common salt solution.

The purpose of the study is to compare the immune response, which is how the body defends itself against infections, when the GBS-NN/NN2 and Tdap vaccines are given together versus when they are given separately. The study will also look at how safe the GBS-NN/NN2 vaccine is and how the body reacts to it, both when it is given alone and when it is given with the Tdap vaccine. Participants in the study will receive the vaccines through an injection into the muscle, known as an intramuscular injection.

During the study, participants will receive the vaccines and will be monitored for any reactions or side effects. The study will track the participants’ health and immune responses over a period of time to gather information on the effectiveness and safety of the vaccines. The trial aims to ensure that the combination of these vaccines does not reduce the immune response compared to when they are given separately. This information will help in understanding the best way to use these vaccines to prevent infections.

]]> Study of GBS-NN/NN2 vaccine to prevent Group B streptococcus infection in healthy pregnant women: evaluating long-term immunity and booster dose safety during subsequent pregnancy https://clinicaltrials.eu/trial/study-on-the-gbs-nn-and-gbs-nn2-vaccines-for-preventing-group-b-streptococcus-infection-in-healthy-pregnant-women/ Wed, 29 Apr 2026 15:05:27 +0000 https://clinicaltrials.eu/trial/study-on-the-gbs-nn-and-gbs-nn2-vaccines-for-preventing-group-b-streptococcus-infection-in-healthy-pregnant-women/ This clinical trial focuses on a vaccine designed to prevent Group B Streptococcus infection. The study examines a vaccine called GBS-NN/NN2, which is given as an injection into the muscle. The purpose is to evaluate how long the immune response lasts after vaccination in pregnant women and to assess the safety and effectiveness of giving an additional booster dose during a subsequent pregnancy.

The vaccine is administered as a solution for injection, with a maximum single dose of 50 micrograms. The study will track how the body maintains protective antibodies over time after the initial vaccination. For some participants who become pregnant again during the study period, a booster dose of the vaccine will be given to examine its effects.

The study will monitor both mothers and their newborns to understand how the vaccine’s protection is passed from mother to baby. Researchers will collect blood samples from mothers at various points during pregnancy and after delivery, as well as from the umbilical cord and infants after birth. The study will also track the general health and development of both mothers and babies to ensure the vaccine’s safety.

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