Gender dysphoria – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:01:01 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Gender dysphoria – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effectiveness of Hormonal Treatment with Estradiol Hemihydrate and Testosterone in Adolescents with Gender Dysphoria https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-hormonal-treatment-with-estradiol-hemihydrate-and-testosterone-in-adolescents-with-gender-dysphoria/ Wed, 29 Apr 2026 14:59:25 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-hormonal-treatment-with-estradiol-hemihydrate-and-testosterone-in-adolescents-with-gender-dysphoria/ This clinical trial is focused on evaluating the effectiveness of hormonal treatment in adolescents experiencing gender dysphoria. Gender dysphoria is a condition where a person feels a strong discomfort with the gender they were assigned at birth. The study involves the use of hormonal treatments, specifically estradiol hemihydrate and testosterone. Estradiol hemihydrate is available in two forms: a film-coated tablet called PROVAMES 1 mg and a gel known as ESTREVA 0.1%. Testosterone is provided in a gel form called ANDROGEL 16.2 mg/g.

The purpose of the study is to assess how these hormonal treatments affect the overall functioning of adolescents with gender dysphoria. The study will follow participants who have completed their social transition and may or may not have undergone prior pubertal suppression. The hormonal treatment will begin when the adolescents are around 14 years old, and their progress will be monitored until they are about 16 years old. The study aims to understand the impact of these treatments on various aspects of the adolescents’ lives, including their mental and physical health.

Participants in the study will receive either estradiol or testosterone, depending on their individual needs. The study will track their development and well-being over a period of time, using various assessments to measure their global functioning. The goal is to gather information that can help improve the care and support provided to adolescents with gender dysphoria. The study is expected to continue until 2031, providing valuable insights into the long-term effects of hormonal treatments in this population.

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