Gambling disorder – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Sat, 30 May 2026 04:03:41 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Gambling disorder – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Testing Psilocybin with Therapy for Treatment of Gambling Disorder in Adults with Problem Gambling https://clinicaltrials.eu/trial/testing-psilocybin-with-therapy-for-treatment-of-gambling-disorder-in-adults-with-problem-gambling/ Wed, 29 Apr 2026 15:08:36 +0000 https://clinicaltrials.eu/trial/testing-psilocybin-with-therapy-for-treatment-of-gambling-disorder-in-adults-with-problem-gambling/ This study looks at gambling disorder, which is a condition where a person has difficulty controlling the urge to gamble despite negative consequences in their life. The study will test a treatment that combines special therapy sessions with psilocybin, a substance found in certain mushrooms that can affect thoughts and feelings. Some participants will receive PEX010 Psilocybin Capsules in different strengths (1.0 mg, 5.0 mg, or 25.0 mg), while others will receive placebo capsules. The capsules are taken by mouth. The purpose of the study is to see if it is possible to conduct a larger research study on this type of therapy for gambling disorder by checking if participants can stay in the study until the end of all planned activities.

The study will involve several visits where participants will receive either psilocybin or placebo during therapy sessions. During these sessions, participants will be closely watched for any changes in heart rate, blood pressure, and behavior or mood. Participants will also complete questionnaires at different times to measure things like their confidence in themselves, how they judge their own condition, their ability to be kind to themselves, their spiritual well-being, and their urges to gamble. Some participants will keep a daily journal to record their cravings. The study will also look at whether the strength of the experience during the psilocybin sessions relates to other personal factors measured at the start of the study.

Throughout the study, researchers will track any unwanted effects that participants experience and will check whether the treatment appears safe. They will also measure whether participants feel the treatment is helpful and whether they are satisfied with the number and length of therapy sessions. The study will assess if enough people agree to join and complete all the planned visits and procedures. Researchers will also gather feedback from both participants and healthcare providers about their experience with this treatment approach. Blood tests and heart tracings will be done to monitor safety.

]]> Study of Ghrelin’s Effects on Decision-Making and Gambling Behavior in Healthy Adults: Comparison with Placebo https://clinicaltrials.eu/trial/study-on-the-effects-of-ghrelin-on-decision-making-in-patients-with-gambling-disorder/ Wed, 29 Apr 2026 15:05:16 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-ghrelin-on-decision-making-in-patients-with-gambling-disorder/ This study examines how lenomorelin (also known as ghrelin), an appetite-stimulating hormone, affects decision-making processes in relation to gambling disorder. The research focuses on understanding how this hormone might influence how people make choices, particularly in situations involving rewards and risks.

During the study, participants will receive either Acyl Ghrelin or sodium chloride solution through an intravenous infusion. The hormone will be administered in carefully controlled doses while participants complete various decision-making tasks. Some participants will also undergo brain imaging using fMRI (functional magnetic resonance imaging) to observe how the hormone affects brain activity during these tasks.

The research consists of two separate studies. The first study looks at how the hormone affects different types of decision-making and brain activity. The second study specifically examines how the hormone influences how people respond to losses in gambling situations. Both studies aim to better understand the relationship between this natural hormone and decision-making behaviors.

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