Ex-tobacco user – European Clinical Trials Information Network

Study on the Safety and Effectiveness of Cytisinicline for Helping Smokers Quit

Wed, 29 Apr 2026 15:04:49 +0000

This clinical trial is focused on helping people who are active smokers and want to quit smoking. The study is testing a treatment called cytisinicline, which is taken as a film-coated tablet. Cytisinicline is a chemical substance that may help people stop smoking by reducing their cravings for cigarettes.

The purpose of the study is to evaluate the safety and effectiveness of cytisinicline when used for different lengths of time. Participants will be randomly assigned to one of three groups, each receiving cytisinicline for either 25, 50, or 75 days. The study will observe how well the treatment works and how safe it is over these different periods. Participants will be monitored at various points during the study to see if they have stopped smoking and to check for any side effects.

The trial will take place over several months, with follow-up checks at 3, 6, and 12 months to assess the participants’ progress in quitting smoking. The study aims to provide valuable information on the best way to use cytisinicline to help people quit smoking safely and effectively.

Study on the Effects of Nicotine Resinate Lozenge on Cravings in Moderate Smokers in Non-Smoking Situations

Wed, 29 Apr 2026 14:57:10 +0000

This clinical trial is focused on helping people who are trying to quit smoking. The study is examining the effects of a nicotine substitute called Nicotine 1.5mg lozenge, which is a small, mint-flavored tablet that dissolves in the mouth. The trial will compare the effects of this lozenge to a placebo, which looks like the lozenge but does not contain any active ingredients. The main goal is to see if the lozenge can help reduce the urge to smoke in people who smoke moderately, which means they smoke between 11 and 20 cigarettes a day.

Participants in the study will be given either the Nicotine 1.5mg lozenge or the placebo. They will take a single dose and then be observed to see how their cravings for cigarettes change over time. The study will look at how cravings are reduced from 30 minutes up to 3 minutes after taking the lozenge. This will help researchers understand if the lozenge is effective in reducing the desire to smoke when people are in situations where they cannot smoke.

The trial is designed to be a fair test, meaning neither the participants nor the researchers will know who is receiving the actual lozenge or the placebo. This is known as a “double-blind” study. The results will help determine if the Nicotine 1.5mg lozenge can be a useful tool for people who want to quit smoking by reducing their cravings in non-smoking situations.

Study on Cytisine for Quitting Nicotine E-Cigarettes and Tobacco in Motivated Individuals

Wed, 29 Apr 2026 14:26:19 +0000

This clinical trial is focused on helping people quit using nicotine-containing electronic cigarettes and tobacco cigarettes. The study is testing a treatment called cytisine, which is a chemical substance used in a tablet form. Participants in the study will receive either cytisine or a placebo, which looks like the cytisine tablet but does not contain the active substance. Both groups will also receive support to help them quit smoking or vaping.

The purpose of the study is to evaluate how effective cytisine is in helping people stop using electronic cigarettes and tobacco cigarettes. Participants who are motivated to quit will be divided into two groups. One group will take cytisine tablets for 12 weeks, while the other group will take placebo tablets for the same period. Both groups will receive behavioral support to assist them in quitting. The study will monitor participants for 30 weeks to see if they can remain smoke-free and vape-free.

Throughout the study, participants will be asked to report their progress and may undergo tests to confirm they have stopped using nicotine products. The goal is to see if cytisine, combined with support, can help people quit smoking and vaping more effectively than support alone. This study aims to provide valuable information on the potential benefits of cytisine for those looking to quit nicotine use.