Erosive oesophagitis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:24:51 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Erosive oesophagitis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of linaprazan glurate and lansoprazole to maintain healing in patients with erosive esophagitis caused by acid reflux disease https://clinicaltrials.eu/trial/study-of-linaprazan-glurate-and-lansoprazole-to-maintain-healing-in-patients-with-erosive-esophagitis-caused-by-acid-reflux-disease/ Thu, 30 Apr 2026 13:08:56 +0000 https://clinicaltrials.eu/trial/study-of-linaprazan-glurate-and-lansoprazole-to-maintain-healing-in-patients-with-erosive-esophagitis-caused-by-acid-reflux-disease/ This study focuses on individuals who have healed erosive esophagitis, which is an inflammation and damage to the lining of the esophagus caused by gastroesophageal reflux disease, a condition where stomach acid flows back up into the food pipe. The purpose of the study is to evaluate the effectiveness and safety of a new medication called linaprazan glurate compared to an existing medication called lansoprazole in keeping the esophagus healed.

Participants in the study will be assigned to receive either linaprazan glurate or lansoprazole. Because the study uses a double-dummy method to ensure that neither the researchers nor the participants know which medication is being taken, some individuals will receive combinations of the active medication and a placebo. The treatment involves taking tablets by oral use over a period of time to see how well the esophagus remains healed and to monitor any potential side effects.

]]> Comparison of linaprazan glurate versus lansoprazole for healing of erosive esophagitis in adults with gastroesophageal reflux disease https://clinicaltrials.eu/trial/comparison-of-linaprazan-glurate-versus-lansoprazole-for-healing-of-erosive-esophagitis-in-adults-with-gastroesophageal-reflux-disease/ Wed, 29 Apr 2026 15:06:37 +0000 https://clinicaltrials.eu/trial/comparison-of-linaprazan-glurate-versus-lansoprazole-for-healing-of-erosive-esophagitis-in-adults-with-gastroesophageal-reflux-disease/ This study focuses on treating erosive esophagitis, a condition where the lining of the food pipe becomes damaged due to gastroesophageal reflux disease (GERD). GERD occurs when stomach acid frequently flows back into the tube connecting the mouth and stomach. The study will compare two medications: linaprazan glurate and lansoprazole, which are both drugs that reduce stomach acid production.

The purpose of this research is to determine if linaprazan glurate is more effective than lansoprazole in healing erosive esophagitis. Some participants will receive linaprazan glurate tablets, while others will receive lansoprazole capsules. Some participants will receive placebo. The treatment will continue for up to 8 weeks.

During the study, doctors will examine the healing of the food pipe using a thin, flexible tube with a camera that allows them to see the condition of the esophagus. Participants will also need to keep track of their symptoms, particularly heartburn, using an electronic diary. The study will monitor any side effects that occur during the treatment period.

]]> Study on Dexlansoprazole for Treating and Maintaining Healing of Erosive Esophagitis in Children Aged 2 to 11 Years https://clinicaltrials.eu/trial/study-on-dexlansoprazole-for-treating-and-maintaining-healing-of-erosive-esophagitis-in-children-aged-2-to-11-years/ Wed, 29 Apr 2026 14:30:27 +0000 https://clinicaltrials.eu/trial/study-on-dexlansoprazole-for-treating-and-maintaining-healing-of-erosive-esophagitis-in-children-aged-2-to-11-years/ This clinical trial is focused on studying a condition known as Erosive Esophagitis in children aged 2 to 11 years. Erosive Esophagitis is a condition where the lining of the esophagus, the tube that carries food from the mouth to the stomach, becomes inflamed and damaged. The study will use a medication called Dexlansoprazole, which is taken orally in the form of a capsule. Dexlansoprazole is designed to help heal the esophagus and maintain its healing over time.

The purpose of the study is to evaluate the safety and effectiveness of Dexlansoprazole in healing Erosive Esophagitis and maintaining the healing in children. Participants will take the medication daily for a period of up to 36 weeks. The study will be conducted in two phases: the first phase will focus on healing the esophagus over 8 weeks, and the second phase will focus on maintaining the healing for an additional 16 weeks. Some participants may receive a placebo during the study.

Throughout the study, participants will be monitored to assess the healing of the esophagus and to ensure the medication is safe for use in children. The study aims to provide valuable information on how well Dexlansoprazole works in treating Erosive Esophagitis in young patients and to ensure it is a safe treatment option. Participants will be required to visit the study site for regular check-ups and assessments during the trial period.

]]> Study on Esomeprazole Magnesium for Maintaining Healing of Erosive Esophagitis in Children Aged 1 to 11 Years https://clinicaltrials.eu/trial/study-on-esomeprazole-magnesium-for-maintaining-healing-of-erosive-esophagitis-in-children-aged-1-to-11-years/ Wed, 29 Apr 2026 14:30:22 +0000 https://clinicaltrials.eu/trial/study-on-esomeprazole-magnesium-for-maintaining-healing-of-erosive-esophagitis-in-children-aged-1-to-11-years/ This clinical trial is focused on studying the condition known as erosive esophagitis, which is a form of inflammation and damage to the esophagus, the tube that carries food from the mouth to the stomach. The study is specifically looking at children aged 1 to 11 years who have this condition. The treatment being tested is called NEXIUM, which contains the active ingredient esomeprazole magnesium. This medication is designed to help maintain the healing of the esophagus after it has been treated for erosive esophagitis.

The purpose of the study is to assess how effective and safe NEXIUM is in keeping the esophagus healed in young patients. Participants in the study will receive the medication in the form of an oral suspension, which is a liquid form that is easy to swallow. The study will take place over a period of several weeks, during which time the children will be monitored to see if their esophagus remains healed and to check for any side effects from the medication.

Throughout the study, the children will have regular check-ups to ensure their safety and to evaluate the condition of their esophagus. The study aims to provide valuable information on how well NEXIUM works in maintaining the healing of erosive esophagitis in children, which could help improve treatment options for this condition in the future.

]]> Study on the Effects and Safety of Pantoprazole for Children and Teens with Healed Erosive Esophagitis https://clinicaltrials.eu/trial/study-on-the-effects-and-safety-of-pantoprazole-for-children-and-teens-with-healed-erosive-esophagitis/ Wed, 29 Apr 2026 14:25:35 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-and-safety-of-pantoprazole-for-children-and-teens-with-healed-erosive-esophagitis/ This clinical trial is focused on studying the effects of a medication called pantoprazole in children and teenagers who have a condition known as erosive esophagitis. Erosive esophagitis is a condition where the lining of the esophagus, the tube that carries food from the mouth to the stomach, becomes inflamed and damaged. The purpose of the study is to explore how well pantoprazole can maintain the healing of this condition in participants aged 1 to 17 years.

Participants in the study will receive pantoprazole in the form of a capsule, which they will take by mouth. The study will compare two different doses of pantoprazole to see which is more effective and safe for maintaining the healing of erosive esophagitis. Some participants may receive a placebo, which looks like the medication but does not contain the active ingredient. The study will last for up to 24 weeks, during which time participants will have regular check-ups to monitor their health and the condition of their esophagus.

The study will assess the safety and tolerability of pantoprazole by conducting physical examinations and monitoring any side effects. Participants will also have their blood pressure and pulse rate checked, and laboratory tests will be performed to ensure their well-being. The main goal is to confirm that the healing of erosive esophagitis is maintained over the course of the study. This research aims to provide valuable information on the use of pantoprazole in young patients with this condition.

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