The purpose of this study is to evaluate whether switching from antibiotics given through a vein to antibiotics taken by mouth earlier in the treatment process works as well as the standard longer treatment with intravenous antibiotics. The study will follow a standardized treatment plan that allows patients to switch to oral antibiotics after a short period of intravenous treatment. This approach aims to determine if patients can be treated effectively with oral medications, which would potentially allow them to complete treatment outside of the hospital setting while maintaining the same level of effectiveness in fighting the infection.

Patients participating in this study will initially receive intravenous antibiotics while admitted to the hospital for less than ten days. After this initial phase, if their condition is stable and the infection is responding to treatment, they may be switched to oral antibiotics according to the study protocol. Throughout the treatment period, which will last for up to six months, patients will be monitored for any signs that the infection is not responding, any complications, or side effects from the medications. The study will track various outcomes including survival, need for heart surgery, new infection-related complications, and patient satisfaction with the treatment approach. Blood samples will be collected at certain times to measure antibiotic levels and ensure the medications are working properly.

The purpose of the study is to determine if a shorter treatment duration is as safe and effective as the standard longer treatment. Participants will receive one of the antibiotics or a combination, and some may receive a placebo. The study will monitor participants for six months to observe any outcomes such as death, septic embolization (a condition where infected particles travel through the bloodstream and block blood vessels), recurrence of the infection, or the need for heart surgery. Additionally, the study will look at hospital-related expenses, the length of hospital stay, the duration of antibiotic treatment, and any complications related to the intravenous administration of the drugs.

Participants will be closely monitored throughout the study period, which will last up to six months. The study will help determine if a shorter course of antibiotics can effectively treat infectious endocarditis, potentially leading to shorter hospital stays and reduced healthcare costs. This research is important for improving treatment strategies and outcomes for patients with this serious heart infection.