Dupuytren’s contracture – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:36:24 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Dupuytren’s contracture – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effectiveness of Collagenase, Percutaneous Needle Fasciotomy, and Limited Fasciectomy for Patients with Mild or Moderate Dupuytren’s Contracture https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-collagenase-percutaneous-needle-fasciotomy-and-limited-fasciectomy-for-patients-with-mild-or-moderate-dupuytrens-contracture/ Wed, 29 Apr 2026 14:59:57 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-collagenase-percutaneous-needle-fasciotomy-and-limited-fasciectomy-for-patients-with-mild-or-moderate-dupuytrens-contracture/ This clinical trial is focused on studying the effectiveness of different treatments for Dupuytren’s contracture, a condition where the fingers bend towards the palm and cannot be fully straightened. The study will compare three treatment methods: collagenase clostridium histolyticum (a medication that helps break down the tough tissue causing the contracture), percutaneous needle fasciotomy (a procedure where a needle is used to cut the cord of tissue causing the contracture), and limited fasciectomy (a surgical procedure to remove the affected tissue).

The purpose of the study is to determine which treatment strategy is the most effective and cost-efficient over a five-year period. Participants will be randomly assigned to one of the three treatment groups. Some participants will receive the collagenase injection, while others will undergo the needle procedure or surgery. The study will follow participants to see how well each treatment works in the short and long term.

Throughout the study, participants will be monitored to assess the success of the treatment they receive. The study aims to provide valuable information on the best approach to managing Dupuytren’s contracture, helping to improve treatment options for this condition in the future.

]]> Study on Percutaneous Needle Fasciotomy with Methylprednisolone Acetate or Saline for Dupuytren’s Contracture in the Finger Joint https://clinicaltrials.eu/trial/study-on-percutaneous-needle-fasciotomy-with-methylprednisolone-acetate-or-saline-for-dupuytrens-contracture-in-the-finger-joint/ Wed, 29 Apr 2026 14:25:10 +0000 https://clinicaltrials.eu/trial/study-on-percutaneous-needle-fasciotomy-with-methylprednisolone-acetate-or-saline-for-dupuytrens-contracture-in-the-finger-joint/ This clinical trial is focused on studying a condition called Dupuytren’s Contracture, which affects the hand, specifically the joints that connect the fingers to the palm. In this condition, the fingers bend towards the palm and cannot be fully straightened. The study is exploring a treatment method called Percutaneous Needle Fasciotomy (PNF), which involves using a needle to cut the thickened tissue in the palm. The trial will compare the effectiveness of PNF when combined with a corticosteroid injection using a medication called Depo-Medrol (methylprednisolone acetate) against PNF with a simple saline injection, which acts as a placebo.

The purpose of the study is to determine if adding a corticosteroid injection to the PNF procedure provides better long-term results in reducing the recurrence of the contracture. The corticosteroid is a type of medication that helps reduce inflammation and is mixed with a local anesthetic called lidocaine to minimize discomfort during the injection. Participants in the study will receive either the corticosteroid and lidocaine mixture or the saline injection after undergoing the PNF procedure.

Throughout the study, participants will be monitored to assess the improvement in their hand function and the degree to which their fingers can be straightened. The study aims to find out if the combination of PNF and corticosteroid injection leads to a lower chance of the contracture returning compared to PNF alone. The trial will also track any side effects or complications that may arise from the treatments. Participants will be followed over time to evaluate the effectiveness and safety of the treatment options being tested.

]]> Study on the Effects of Adalimumab and Saline in Patients Undergoing Needle Fasciotomy for Dupuytren’s Disease https://clinicaltrials.eu/trial/study-on-the-effects-of-adalimumab-and-saline-in-patients-undergoing-needle-fasciotomy-for-dupuytrens-disease/ Wed, 29 Apr 2026 14:23:58 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-adalimumab-and-saline-in-patients-undergoing-needle-fasciotomy-for-dupuytrens-disease/ This clinical trial is focused on studying a condition known as Dupuytren’s Disease, which affects the hands and can cause fingers to bend towards the palm. The study is investigating whether a medication called Adalimumab, which is an anti-TNF (tumor necrosis factor) treatment, can improve the results of a procedure called needle fasciotomy. This procedure is used to treat Dupuytren’s Disease by cutting the thickened tissue in the palm to help straighten the fingers.

The purpose of the study is to see if using Adalimumab can lead to better outcomes for patients undergoing this procedure. Participants in the study will receive either the medication or a placebo, which is a substance with no active drug. The study will last for a period of time, during which participants will receive injections and be monitored for changes in their condition. The goal is to determine if there is an improvement in finger movement and overall satisfaction with the treatment.

Throughout the study, participants will be assessed on various factors, including the degree of finger straightening, recurrence of the condition, pain levels, and overall satisfaction with the treatment. The study aims to provide valuable information on whether Adalimumab can be an effective addition to the treatment of Dupuytren’s Disease when combined with needle fasciotomy.

]]> Study on the Safety and Effectiveness of Vibrio Alginolyticus Collagenase for Patients with Dupuytren’s Contracture https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-vibrio-alginolyticus-collagenase-for-patients-with-dupuytrens-contracture/ Wed, 29 Apr 2026 14:23:02 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-vibrio-alginolyticus-collagenase-for-patients-with-dupuytrens-contracture/ This clinical trial is focused on studying a condition known as Dupuytren’s contracture. This condition affects the hands, causing one or more fingers to bend towards the palm due to a thickening of the tissue under the skin. The study is testing a treatment called Vibrio alginolyticus collagenase, which is a type of enzyme that breaks down proteins. This enzyme is injected directly into the affected area to help reduce the contracture, or bending, of the fingers.

The purpose of the study is to evaluate the safety and effectiveness of this treatment. The study is divided into two phases. In the first phase, different doses of the enzyme will be tested to find the safest and most effective dose. In the second phase, the dose identified in the first phase will be used to see how well it works in a larger group of patients. Some participants will receive the enzyme, while others will receive a matching placebo, which looks like the treatment but does not contain the active enzyme.

Participants in the study will receive up to three injections of the enzyme into the affected area. The study will monitor the participants to see if the treatment helps reduce the bending of the fingers and improves hand function. The study will also check for any side effects or immune reactions to the enzyme. The goal is to determine if Vibrio alginolyticus collagenase is a safe and effective treatment option for people with Dupuytren’s contracture.

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