Device related infection – European Clinical Trials Information Network

Study comparing dalbavancin to standard antibiotic treatment for patients with periprosthetic joint infection

Thu, 30 Apr 2026 13:08:09 +0000

This clinical trial studies the treatment of periprosthetic joint infection, which is an infection occurring around artificial joints in the knee, hip, or shoulder. The study compares two treatment approaches: a new antibiotic called dalbavancin versus standard antibiotic therapy. Standard antibiotics that may be used include amoxicillin, linezolid, flucloxacillin, gentamicin, vancomycin, and several others.

The main purpose of the study is to compare the costs and effectiveness of these treatments while also looking at how they affect patients’ quality of life. The study will measure antibiotic levels in bone and tissue, track physical activity during treatment, and examine how the medications affect bacteria in the digestive system.

Treatment will last between 6 and 12 weeks, depending on the specific case. Patients will be monitored for up to one year to check for any complications or return of infection. During the study, participants will wear an activity tracker and complete questionnaires about their health and quality of life. Some participants will also provide tissue samples for laboratory analysis.

Using fludeoxyglucose (18F) in PET/CT imaging to diagnose and monitor cardiovascular device infections

Wed, 29 Apr 2026 15:09:52 +0000

This study focuses on Cardiovascular device infections, which are infections that occur in medical devices placed in the heart or blood vessels, such as pacemakers or artificial valves. The purpose of the study is to determine if a specialized way of looking at medical images can better identify these infections. To do this, an imaging technique called PET/CT, which uses a computed tomography scan combined with a specialized camera, will be used. This process involves an intravenous injection of a radioactive substance called fludeoxyglucose (18F), a type of sugar marked with a tracer that allows doctors to see how cells are using energy in the body.

During the study, radiomics will be applied to the images. This is a method that uses computers to extract large amounts of detailed data from medical scans that are not visible to the human eye. These computer-generated details are then analyzed to help distinguish between an actual infection and other types of inflammation. This approach may help in predicting whether an infection is healing, which could eventually help in deciding when it is safe to stop using long-term antimicrobial therapy, which is medication used to fight bacteria.

Study Comparing Rifabutin and Rifampicin for Adults with Staphylococcal Prosthetic Joint Infection Using DAIR Strategy

Wed, 29 Apr 2026 15:02:44 +0000

This clinical trial is focused on treating a type of infection called staphylococcal prosthetic joint infection. This infection occurs in people who have had joint replacement surgery, such as a hip or knee replacement, and is caused by bacteria known as staphylococci. The study is comparing two medications: Rifabutin and Rifampicin. Both are antibiotics taken orally in the form of capsules. The goal is to see if Rifabutin is as effective as Rifampicin in treating this infection.

The study will involve participants who have this type of infection and are being treated with a method called the DAIR strategy, which stands for debridement, antibiotics, and implant retention. This means that the infected area is cleaned, antibiotics are given, and the joint implant is kept in place. Participants will be randomly assigned to receive either Rifabutin or Rifampicin for a period of up to 12 weeks. The study will monitor the participants for one year to see if the treatment is successful and if there are any side effects.

The main focus is to determine if the infection is effectively treated without the need for additional surgery, and to ensure that the treatment does not cause serious side effects. Participants’ quality of life and any changes in their condition will also be assessed over a period of up to two years. This study aims to provide valuable information on the best treatment options for people with staphylococcal prosthetic joint infections.

Study of Cefazolin for Patients on Chronic Hemodialysis with Infections

Wed, 29 Apr 2026 14:26:37 +0000

This clinical trial focuses on patients undergoing chronic hemodialysis who are suffering from infections. The study is examining the use of a medication called cefazolin, which is a type of antibiotic used to treat bacterial infections. The purpose of the study is to understand how cefazolin behaves in the body of patients who are on long-term dialysis treatment.

Participants in the study will receive cefazolin as part of their regular care. The study will monitor how the medication is processed in the body, specifically looking at how long the drug stays in the bloodstream at effective levels. This will help determine the best way to use cefazolin in treating infections in these patients. The study will also observe any side effects that may occur within six weeks after the last dose of the medication.

Throughout the study, researchers will assess the early and late effectiveness of cefazolin in treating infections. Early effectiveness will be checked one week after starting treatment, while late effectiveness will be evaluated six weeks after starting treatment. The study aims to ensure that the medication is working properly and to identify any factors that might affect how the drug is processed in the body. This information will be valuable in improving treatment for patients with infections who are on chronic hemodialysis.