Desmoplastic small round cell tumour – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:18:38 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Desmoplastic small round cell tumour – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of lurbinectedin and irinotecan in adults and young adults with advanced desmoplastic small round cell tumor https://clinicaltrials.eu/trial/study-of-lurbinectedin-and-irinotecan-in-adults-and-young-adults-with-advanced-desmoplastic-small-round-cell-tumor/ Thu, 30 Apr 2026 13:08:04 +0000 https://clinicaltrials.eu/trial/study-of-lurbinectedin-and-irinotecan-in-adults-and-young-adults-with-advanced-desmoplastic-small-round-cell-tumor/ This clinical trial is studying the effectiveness of combining two medications – lurbinectedin and irinotecan – in treating desmoplastic small round cell tumor (DSRCT), a rare type of cancer. The study is designed for adults and young adults who have advanced forms of this disease that have continued to progress after previous treatments.

The study will use lurbinectedin, which is given as a powder that is made into a solution for infusion, and irinotecan, which is given as a solution directly into the vein. These medications will be given to patients whose cancer has grown or spread after receiving between one to three previous treatments that included drugs called anthracyclines.

The main goal is to see how well tumors respond to this combination of medications. The researchers will also track how long patients survive, how long they live without their disease getting worse, and monitor any side effects. Patients will also complete questionnaires about their quality of life and pain levels during the treatment period.

]]> Study on the Safety and Effectiveness of CEB-01 for Children with Resectable Tumors https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-ceb-01-for-children-with-resectable-tumors/ Wed, 29 Apr 2026 15:04:35 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-ceb-01-for-children-with-resectable-tumors/ This clinical trial is focused on studying certain types of childhood cancers, specifically those that can be surgically removed from the abdomen. The cancers being studied include extracranial malignant rhabdoid tumor, desmoplastic small round cell tumor, germ cell tumor, Wilms tumor, synovial sarcoma, high-risk neuroblastoma, soft-tissue sarcoma, and fibrolamellar hepatocellular carcinoma. The treatment being tested is a new formulation called CEB-01, which contains the active substance 7-ethyl-10-hydroxycamptothecin. This substance is delivered through a special material that can be implanted in the body.

The purpose of the study is to evaluate the safety and tolerability of CEB-01 when used alongside standard cancer treatments. The study will involve children from birth to under 18 years of age who have these specific types of tumors. Participants will receive the new treatment in addition to their usual care, and the effects will be compared to those who receive only the standard treatment. The study will monitor for any side effects and how well the treatment works in preventing the cancer from coming back or spreading.

Throughout the study, researchers will collect information on the participants’ health and how their bodies process the treatment. This includes measuring the levels of the drug in the blood and observing any changes in the tumors. The study aims to provide valuable information on the potential benefits and risks of using CEB-01 in treating these childhood cancers.

]]> Study on Pasireotide for Patients with Synovial Sarcoma and Desmoplastic Small Round Cell Tumor https://clinicaltrials.eu/trial/study-on-pasireotide-for-patients-with-synovial-sarcoma-and-desmoplastic-small-round-cell-tumor/ Wed, 29 Apr 2026 14:57:58 +0000 https://clinicaltrials.eu/trial/study-on-pasireotide-for-patients-with-synovial-sarcoma-and-desmoplastic-small-round-cell-tumor/ This clinical trial is focused on studying two types of rare cancers: synovial sarcoma and desmoplastic small round cell tumor. These are serious conditions that can occur in various parts of the body and are often difficult to treat. The study will use a medication called pasireotide, which is given as a suspension for injection. This means the medicine is in liquid form and is injected into the muscle.

The purpose of the study is to see if pasireotide can help patients with these cancers live longer without the disease getting worse. Patients will receive the medication through a deep intramuscular injection once a month. The study will compare the effects of pasireotide with a placebo to understand its effectiveness better. The trial will last for a period of time, during which patients will be monitored regularly to check on their health and the progress of their disease.

Participants in the study will include those who have already received standard treatments for their cancer and have shown stable disease or some improvement. The study aims to provide more information on whether pasireotide can be a beneficial maintenance treatment for these specific types of cancer. The ultimate goal is to improve the quality of life and survival rates for patients with synovial sarcoma and desmoplastic small round cell tumor.

]]> Study of Trabectedin and Low-Dose Radiation Therapy for Adults and Young Adults with Advanced or Metastatic Soft Tissue and Bone Sarcomas https://clinicaltrials.eu/trial/study-of-trabectedin-and-low-dose-radiation-therapy-for-adults-and-young-adults-with-advanced-or-metastatic-soft-tissue-and-bone-sarcomas/ Wed, 29 Apr 2026 14:29:09 +0000 https://clinicaltrials.eu/trial/study-of-trabectedin-and-low-dose-radiation-therapy-for-adults-and-young-adults-with-advanced-or-metastatic-soft-tissue-and-bone-sarcomas/ This clinical trial focuses on patients with advanced/metastatic sarcomas, which are cancers that develop in soft tissues, bones, or appear as small round-cell tumors. The study specifically looks at three types: soft tissue sarcoma, bone tumors (including osteosarcoma and chondrosarcoma), and small round-cell sarcomas (including Ewing’s sarcoma, rhabdomyosarcoma, and other related tumors).

The study combines two types of treatment: a medication called trabectedin (given through an intravenous infusion) and low-dose radiation therapy. Trabectedin is administered as a solution that is prepared from a powder and given through a special tube placed in a vein. The dose used in this study is 1.5 milligrams per square meter of body surface.

The main goal of this research is to determine how well tumors respond to this combination treatment, particularly in areas that receive radiation therapy. Throughout the study, researchers will monitor changes in tumor size, track how long the treatment remains effective, and assess its effects on pain levels and overall well-being. They will also carefully watch for any side effects that may occur during treatment.

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