Desmoid tumour – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 16 Jun 2026 04:02:18 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Desmoid tumour – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of Nirogacestat in adult premenopausal women with desmoid tumors and aggressive fibromatosis to evaluate ovarian function recovery https://clinicaltrials.eu/trial/study-of-nirogacestat-in-adult-premenopausal-women-with-desmoid-tumors-and-aggressive-fibromatosis-to-evaluate-ovarian-function-recovery/ Wed, 29 Apr 2026 15:07:27 +0000 https://clinicaltrials.eu/trial/study-of-nirogacestat-in-adult-premenopausal-women-with-desmoid-tumors-and-aggressive-fibromatosis-to-evaluate-ovarian-function-recovery/ This study focuses on desmoid tumors/aggressive fibromatosis (DT/AF), which are rare growths that develop in soft tissues. The study will test a medication called nirogacestat (also known as PF-03084014) that comes in tablet form and is taken by mouth. This medicine will be given to adult women before menopause who have these tumors.

The main purpose of this research is to understand how the treatment affects ovarian function in women. The study will look at whether and how quickly normal menstrual cycles and hormone levels return after treatment. Participants will take the medication daily for up to 24 months.

During the study, doctors will monitor participants’ overall health, including regular blood tests to check hormone levels and track menstrual cycles. The medication dose can be up to 300 milligrams per day. This is an open-label study, which means all participants will receive the active medication, and there is no placebo group.

]]> Study of Propranolol and Vinorelbine for Children and Teenagers with Refractory or Relapsing Solid Tumors https://clinicaltrials.eu/trial/study-of-propranolol-and-vinorelbine-for-children-and-teenagers-with-refractory-or-relapsing-solid-tumors/ Wed, 29 Apr 2026 14:59:48 +0000 https://clinicaltrials.eu/trial/study-of-propranolol-and-vinorelbine-for-children-and-teenagers-with-refractory-or-relapsing-solid-tumors/ This clinical trial is focused on studying treatments for children and teenagers with refractory or relapsing solid tumors. These are types of cancer that have not responded to previous treatments or have returned after treatment. The study will use a combination of two medications: Propranolol and Vinorelbine. Propranolol is commonly used to treat heart conditions, while Vinorelbine is a chemotherapy drug used to treat cancer. The purpose of the study is to determine the highest dose of Vinorelbine that can be given safely when combined with Propranolol.

Participants in the study will take Vinorelbine three times a week and Propranolol daily. The study will monitor how well participants tolerate the treatment and will assess any side effects. The trial will also evaluate how effective the treatment is in controlling the cancer over a period of six months. The study aims to find the best dose that balances effectiveness with minimal side effects.

This trial is important for finding new ways to treat children and teenagers with difficult-to-treat cancers. By combining these two medications, researchers hope to improve outcomes for patients who have limited treatment options. The study will provide valuable information on the safety and potential benefits of this treatment combination.

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