Contraception – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 23 Jun 2026 04:06:54 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Contraception – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 A study comparing the effects of estetrol and drospirenone, ethinylestradiol and drospirenone, and drospirenone in women with polycystic ovary syndrome (PCOS) https://clinicaltrials.eu/trial/a-study-comparing-the-effects-of-estetrol-and-drospirenone-ethinylestradiol-and-drospirenone-and-drospirenone-in-women-with-polycystic-ovary-syndrome-pcos/ Wed, 29 Apr 2026 15:10:01 +0000 https://clinicaltrials.eu/trial/a-study-comparing-the-effects-of-estetrol-and-drospirenone-ethinylestradiol-and-drospirenone-and-drospirenone-in-women-with-polycystic-ovary-syndrome-pcos/ This study focuses on women with Polycystic Ovary Syndrome, a condition that affects hormone levels. The purpose of the study is to investigate how different types of contraception, which are methods used to prevent pregnancy, affect blood clotting. Participants will be assigned to use different medications taken by mouth, including estetrol and drospirenone, ethinylestradiol and drospirenone, or only drospirenone.

During the trial, individuals will take one of the three different medication combinations for a period of six months. The study will look at how these treatments impact coagulation, which is the process the body uses to form clots in the blood. By comparing these options, researchers aim to see if certain hormone combinations have a smaller effect on the blood’s ability to clot compared to others.

]]> Contraception study in women: comparing oral drospirenone‑only, drospirenone + ethinylestradiol, and drospirenone + estetrol tablets https://clinicaltrials.eu/trial/contraception-study-in-women-comparing-oral-drospirenone-only-drospirenone-ethinylestradiol-and-drospirenone-estetrol-tablets/ Wed, 29 Apr 2026 15:09:58 +0000 https://clinicaltrials.eu/trial/contraception-study-in-women-comparing-oral-drospirenone-only-drospirenone-ethinylestradiol-and-drospirenone-estetrol-tablets/ The trial looks at women who need birth control, called contraception, and compares three oral pill formulations. One pill contains the hormone drospirenone together with the newer estrogen estetrol, another combines drospirenone with the traditional estrogen ethinylestradiol, and a third contains only drospirenone without any estrogen.

The main purpose is to see whether the pill with estetrol and drospirenone has a smaller effect on blood clotting, measured by a laboratory test called endogenous thrombin potential, compared with the pill that uses ethinylestradiol and drospirenone, while the drospirenone‑only pill is expected to have little impact on clotting.

Participants will be assigned to take one of the three pills every day for about a year. They will attend routine visits, and at the end of the 12‑month period they will have a final check to assess how the medication affected the body. No additional procedures beyond the regular pill use and scheduled visits are required.

]]> Study on the Effectiveness and Safety of Levonorgestrel Vaginal Delivery System vs. Desogestrel Tablets for Preventing Pregnancy in Women https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-levonorgestrel-vaginal-delivery-system-vs-desogestrel-tablets-for-preventing-pregnancy-in-women/ Wed, 29 Apr 2026 15:05:50 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-levonorgestrel-vaginal-delivery-system-vs-desogestrel-tablets-for-preventing-pregnancy-in-women/ This clinical trial is focused on the prevention of pregnancy and involves two treatments. The first treatment is the Levonorgestrel Vaginal Delivery System, which is a system designed to release the hormone levonorgestrel directly into the body. The second treatment is a tablet called Desirett 75 Mikrogramm Filmtabletten, which contains the hormone desogestrel. Both treatments are being studied for their effectiveness, safety, and how well they are tolerated by users.

The purpose of the study is to demonstrate the contraceptive effectiveness of the Levonorgestrel Vaginal Delivery System. Participants in the study will be randomly assigned to use either the vaginal delivery system or the oral tablet for nine cycles, each lasting 28 days. The study will compare how well each method prevents pregnancy and will also monitor any side effects or health changes experienced by participants.

Throughout the study, participants will be observed for any adverse events, changes in vital signs, and overall health through physical and gynecological examinations. The study will also assess the quality of life and satisfaction of participants using a questionnaire. The trial aims to provide valuable information on the effectiveness and safety of these contraceptive methods over the course of the study period.

]]> Study on the Effectiveness and Safety of Levonorgestrel Vaginal Delivery System for Preventing Pregnancy in Women https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-levonorgestrel-vaginal-delivery-system-for-preventing-pregnancy-in-women/ Wed, 29 Apr 2026 15:05:39 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-levonorgestrel-vaginal-delivery-system-for-preventing-pregnancy-in-women/ This clinical trial is focused on the prevention of pregnancy using a treatment called the Levonorgestrel Vaginal Delivery System 75, also known by its code name CH211-75. The study aims to evaluate how effective, safe, and tolerable this system is as a contraceptive method over the course of 13 menstrual cycles. The Levonorgestrel Vaginal Delivery System is a device designed for vaginal use that releases a hormone called levonorgestrel, which is commonly used in various forms of birth control.

Participants in the study will use the Levonorgestrel Vaginal Delivery System for thirteen 28-day cycles. Throughout the study, researchers will monitor the participants to assess the system’s ability to prevent pregnancy and to observe any side effects or changes in health. The study will also look at how the system affects the quality of life and satisfaction of the participants. Additionally, for younger participants, the study will explore any changes in bone health using a method called DXA, which is a type of scan that measures bone density.

The purpose of this study is to demonstrate the contraceptive efficacy of the Levonorgestrel Vaginal Delivery System. Participants will be observed for any adverse events, changes in vital signs, and other health indicators to ensure the safety and tolerability of the treatment. The study will provide valuable information on how well this contraceptive method works and its impact on users’ health and well-being.

]]> Study on Menstrual Bleeding and Tolerability of Norgestimate and Ethinylestradiol for Women Using Contraceptives in Italy https://clinicaltrials.eu/trial/study-on-menstrual-bleeding-and-tolerability-of-norgestimate-and-ethinylestradiol-for-women-using-contraceptives-in-italy/ Wed, 29 Apr 2026 15:03:53 +0000 https://clinicaltrials.eu/trial/study-on-menstrual-bleeding-and-tolerability-of-norgestimate-and-ethinylestradiol-for-women-using-contraceptives-in-italy/ This clinical trial is focused on studying the effects of a hormonal contraceptive treatment for women. The treatment being tested is a monophasic oral contraceptive pill called Effimia, which contains two active substances: norgestimate and ethinylestradiol. These substances are commonly used in birth control pills to prevent pregnancy. The study aims to evaluate how well this contraceptive controls the menstrual cycle, specifically looking at any unexpected bleeding or spotting that may occur between regular menstrual periods.

The purpose of the study is to understand the pattern of menstrual bleeding, how well the treatment is tolerated, and how consistently it is used by participants. Women participating in the study will take the contraceptive pill for a period of six months. During this time, researchers will monitor various aspects of their menstrual cycle, including the frequency and volume of bleeding, as well as any unscheduled bleeding. Additionally, the study will assess other factors such as acne, mood, sexual function, and menstrual pain using simple questionnaires and scales.

Throughout the study, researchers will also keep track of how well participants adhere to the treatment and whether there are any instances of contraceptive failure, meaning if any participants become pregnant during the study. The study is conducted in Italy and involves women who are in need of contraception. By the end of the study, the researchers hope to gather valuable information about the effectiveness and user experience of the Effimia contraceptive pill.

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