Congenital pseudarthrosis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:18:27 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Congenital pseudarthrosis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of NVD003 stem cell implant compared to bone graft for children with congenital pseudarthrosis of the tibia https://clinicaltrials.eu/trial/study-of-nvd003-stem-cell-implant-compared-to-bone-graft-for-children-with-congenital-pseudarthrosis-of-the-tibia/ Wed, 29 Apr 2026 15:06:50 +0000 https://clinicaltrials.eu/trial/study-of-nvd003-stem-cell-implant-compared-to-bone-graft-for-children-with-congenital-pseudarthrosis-of-the-tibia/ This study focuses on children with Congenital Pseudarthrosis of the Tibia, a rare condition where the shin bone develops an abnormal connection that doesn’t heal properly. The study will test a treatment called NVD003, which is made from a patient’s own fat-derived stem cells and is surgically implanted into the affected bone area. This treatment will be compared to the current standard procedure that uses bone tissue taken from the hip bone.

The purpose of this research is to determine how well NVD003 works and how safe it is when used to treat children with this bone condition. The study involves a surgical procedure where either NVD003 or hip bone tissue will be implanted along with an internal rod to help stabilize the bone. The treatment will be monitored for 12 months to check how well the bone heals.

During the study, doctors will take X-rays and perform physical examinations to check bone healing. They will also assess the child’s ability to walk and their overall quality of life. The study will track any side effects that might occur during and after the surgical procedure. Children participating in the study will need to visit the hospital several times over the course of one year for these evaluations.

]]> Study on NVD-003 Bone Graft for Treating Congenital Pseudarthrosis of the Tibia in Children https://clinicaltrials.eu/trial/study-on-nvd-003-bone-graft-for-treating-congenital-pseudarthrosis-of-the-tibia-in-children/ Wed, 29 Apr 2026 14:27:46 +0000 https://clinicaltrials.eu/trial/study-on-nvd-003-bone-graft-for-treating-congenital-pseudarthrosis-of-the-tibia-in-children/ This clinical trial is focused on studying a rare bone condition called , which affects children. This condition involves a bone in the lower leg, known as the tibia, that does not heal properly after a fracture. The study is testing a new treatment called , which is an implant made from the patient’s own fat-derived stem cells. These cells are used to create a bone graft that can help the tibia heal.

The purpose of the study is to assess the safety of the treatment. The study will involve a procedure to collect fat tissue from the patient, which will then be used to create the bone graft. This graft will be implanted into the affected area of the tibia. The study will monitor the patients over a period of time to ensure the treatment is safe and to observe how well the bone heals.

Participants in the study will undergo regular check-ups, including imaging tests like X-rays, to track the progress of the bone healing. The study will last for about two years, during which the safety and effectiveness of the treatment will be closely monitored. This research aims to provide a new option for children with this challenging condition, potentially improving their ability to heal and function normally.

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