Congenital ectodermal dysplasia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 10:55:57 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Congenital ectodermal dysplasia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on ER004 for Treating Boys with X-linked Hypohidrotic Ectodermal Dysplasia (XLHED) https://clinicaltrials.eu/trial/study-on-er004-for-treating-boys-with-x-linked-hypohidrotic-ectodermal-dysplasia-xlhed/ Wed, 29 Apr 2026 14:28:34 +0000 https://clinicaltrials.eu/trial/study-on-er004-for-treating-boys-with-x-linked-hypohidrotic-ectodermal-dysplasia-xlhed/ This clinical trial is focused on studying a rare genetic condition called X-linked hypohidrotic ectodermal dysplasia (XLHED). This condition affects the development of certain tissues in the body, leading to symptoms such as reduced ability to sweat, dental issues, and skin problems. The trial is testing a treatment called ER004, which is a special protein designed to help improve these symptoms. The treatment is given as a solution for injection directly into the amniotic fluid surrounding the fetus during pregnancy.

The purpose of the study is to evaluate how effective and safe ER004 is when administered before birth to male fetuses diagnosed with XLHED. The study will compare the sweating ability of treated infants at six months of age with that of untreated relatives who have the same genetic mutation. The trial will also look at other aspects of health, such as dental development, skin condition, and overall quality of life.

Participants in the study will receive the treatment during pregnancy, and the health of the infants will be monitored after birth. This includes checking their ability to sweat, the number of teeth that have developed, and other health indicators. The study aims to provide valuable information on whether this prenatal treatment can help improve the symptoms of XLHED in affected individuals.

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