Complications of transplanted heart – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:36:20 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Complications of transplanted heart – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of belatacept, tacrolimus and ciclosporin in heart transplant patients at risk of kidney failure https://clinicaltrials.eu/trial/study-on-belatacept-for-heart-transplant-patients-at-risk-of-chronic-kidney-disease-with-tacrolimus-and-ciclosporin-drug-combination/ Wed, 29 Apr 2026 14:59:50 +0000 https://clinicaltrials.eu/trial/study-on-belatacept-for-heart-transplant-patients-at-risk-of-chronic-kidney-disease-with-tacrolimus-and-ciclosporin-drug-combination/ This study focuses on patients who have undergone heart transplantation and are at risk of developing chronic kidney failure. The research examines the effectiveness of belatacept, a medication given through intravenous infusion, as an alternative treatment that may be less harmful to the kidneys compared to standard medications. The other medications used in the study include tacrolimus, which comes as capsules under the brand names Advagraf and Prograf, and ciclosporin (Neoral) soft capsules.

The purpose of this research is to determine if belatacept can help improve kidney function in heart transplant patients when used together with gradually reduced doses of traditional anti-rejection medications. The study will last for 12 months after heart transplantation, during which patients will receive monthly infusions of belatacept.

During the study, patients will have their kidney function monitored through blood tests. The research team will also perform myocardial biopsies (heart tissue samples) and check for signs of organ rejection. Additionally, patients will be monitored for blood sugar levels and other health indicators to ensure their safety throughout the treatment period.

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