Colonoscopy – European Clinical Trials Information Network

Efficacy and Safety of Mannitol Compared to Plenvu for Bowel Preparation in Patients Undergoing Elective Colonoscopy

Wed, 29 Apr 2026 15:06:19 +0000

This study evaluates the effectiveness of two different bowel preparation methods for patients undergoing elective colonoscopy. A colonoscopy is a procedure where a doctor examines the lining of the large intestine (colon) using a flexible tube with a camera. Before this procedure, the bowel must be thoroughly cleaned to allow clear visualization. The study compares mannitol (a type of sugar alcohol used as a bowel cleanser) with Plenvu® (a commercially available bowel preparation solution) to determine if mannitol works at least as well as Plenvu® for cleaning the bowel.

The purpose of this research is to show that mannitol is not inferior to Plenvu® when used as a same-day bowel preparation regimen before colonoscopy. Participants will be randomly assigned to use either mannitol or Plenvu® to clean their bowels before their scheduled colonoscopy. The endoscopist (the doctor performing the colonoscopy) will not know which preparation each patient received, allowing for an unbiased assessment of how clean the bowel is during the procedure.

During the study, patients will take their assigned bowel preparation according to instructions, undergo their scheduled colonoscopy, and answer questions about their experience with the preparation, including ease of use, taste, and willingness to use it again. The study will also monitor for any side effects from either preparation and collect information about how well each preparation cleaned the bowel and allowed for detection of any abnormalities.

Study Comparing Bowel Cleansing Agents Plenvu and Picoprep for Patients Undergoing Colonoscopy to Exclude Colorectal Cancer

Wed, 29 Apr 2026 14:58:16 +0000

This clinical trial is focused on comparing two bowel cleansing agents, Plenvu and Picoprep, which are used before a colonoscopy. A colonoscopy is a procedure that allows doctors to examine the inside of the large bowel using a fiberoptic device. The purpose of this study is to determine how effective and tolerable these two cleansing agents are when preparing the bowel for this examination. The patients involved in this study are those who are being checked to rule out colorectal cancer. The cleansing process is important because it helps improve the visibility of the bowel lining, which is crucial for the quality of the colonoscopy.

Plenvu is a relatively new bowel preparation that contains substances like ascorbic acid (also known as Vitamin C), sodium ascorbate, potassium chloride, sodium chloride, and macrogol 3350. It is a low-volume solution that is taken orally. On the other hand, Picoprep is a well-established preparation that includes sodium picosulfate, magnesium oxide, and citric acid. This study aims to see if Plenvu is as effective as Picoprep in cleaning the bowel and if it is easier for patients to tolerate.

Participants in the study will be randomly assigned to receive either Plenvu or Picoprep before their colonoscopy. The study will monitor how well each agent cleans the bowel and how patients feel about taking them. The trial will help determine if Plenvu can provide a similar or better experience compared to Picoprep in terms of both effectiveness and patient comfort.