Colon cancer stage IV – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:13:20 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Colon cancer stage IV – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Pre-Operative Chemotherapy with Disodium Folinate, Oxaliplatin, and Fluorouracil for Patients with Advanced Resectable Colon Cancer https://clinicaltrials.eu/trial/study-on-pre-operative-chemotherapy-with-disodium-folinate-oxaliplatin-and-fluorouracil-for-patients-with-advanced-resectable-colon-cancer/ Wed, 29 Apr 2026 15:02:03 +0000 https://clinicaltrials.eu/trial/study-on-pre-operative-chemotherapy-with-disodium-folinate-oxaliplatin-and-fluorouracil-for-patients-with-advanced-resectable-colon-cancer/ This clinical trial is focused on studying the effects of pre-operative treatment in patients with colon cancer. The trial involves patients whose cancer is at an advanced stage, specifically stages T3-4, and/or those with positive lymph nodes as identified by CT or MRI scans, but without cancer spread to distant parts of the body. The purpose of the study is to compare the effectiveness of chemotherapy given before surgery with the standard approach of surgery followed by additional treatment based on the cancer stage.

The study will use several medications, including Disodium Folinate, Oxaliplatin, Fluorouracil, Irinotecan, Capecitabine, and Calcium Folinate. These medications are administered either as solutions for infusion, which means they are given directly into the bloodstream, or as tablets taken by mouth. Some participants will receive these medications, while others may receive a placebo. The trial will last for a maximum of 24 months, during which the participants will receive the treatment and be monitored for their response to it.

The main goal is to see if the pre-operative chemotherapy can improve the time patients remain free from the disease, known as disease-free survival. This means the study will look at whether patients have no surgery, no resection, incomplete resection, new metastases, local relapse, or death from any cause after starting the trial. The trial aims to provide valuable information on whether starting treatment before surgery can offer better outcomes for patients with advanced colon cancer.

]]> Study on High-Dose Vitamin C with Ipilimumab and Nivolumab for Patients with Colorectal Cancer https://clinicaltrials.eu/trial/study-on-high-dose-vitamin-c-with-ipilimumab-and-nivolumab-for-patients-with-colorectal-cancer/ Wed, 29 Apr 2026 14:24:41 +0000 https://clinicaltrials.eu/trial/study-on-high-dose-vitamin-c-with-ipilimumab-and-nivolumab-for-patients-with-colorectal-cancer/ This clinical trial is focused on studying the effects of a combination treatment for patients with a specific type of colon cancer known as mismatch repair proficient colorectal cancer. The treatment being tested includes three components: Ipilimumab, Nivolumab, and high-dose Vitamin C. Ipilimumab and Nivolumab are medications that help the immune system fight cancer, and they are given as a solution through an infusion, which means they are delivered directly into the bloodstream. Vitamin C, commonly known as ascorbic acid, is also given in high doses through an infusion.

The purpose of this study is to see how well this combination of treatments works when given before surgery to remove the cancer. The study will involve patients receiving these treatments over a period of time before they undergo surgery. During the study, some patients may receive a placebo, which is a substance with no active medication, to compare the effects of the actual treatment. The study aims to understand if this combination can improve the response of the cancer to treatment before surgery.

Participants in the study will receive the treatments in a controlled setting, and their health will be monitored closely by medical professionals. The study will help researchers learn more about the potential benefits and any side effects of using Ipilimumab, Nivolumab, and high-dose Vitamin C together in treating this type of colon cancer. This research is important for developing new ways to treat cancer and improve outcomes for patients.

]]>