Chronic sinusitis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:30:48 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Chronic sinusitis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effectiveness and Safety of LYR-210 and Dexamethasone for Treating Chronic Sinusitis in Adults Without Nasal Polyps https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-lyr-210-and-dexamethasone-for-treating-chronic-sinusitis-in-adults-without-nasal-polyps/ Wed, 29 Apr 2026 14:26:39 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-lyr-210-and-dexamethasone-for-treating-chronic-sinusitis-in-adults-without-nasal-polyps/ This clinical trial is focused on studying the treatment of Chronic Rhinosinusitis (CRS) in adults. CRS is a condition where the sinuses, which are air-filled spaces in the face, become inflamed and swollen for a long time, leading to symptoms like nasal blockage, facial pain, and nasal discharge. The study will evaluate a treatment called the LYR-210 System, which is a powder for inhalation containing the active substance Mometasone Furoate. This treatment is compared to a sham procedure, which is a fake treatment used for comparison purposes.

The purpose of the study is to assess how effective the LYR-210 System is in improving the main symptoms of CRS in participants who do not have nasal polyps and have not responded well to previous medical treatments. Participants will receive the treatment through intranasal use, meaning it is administered through the nose. The study will last for about 24 weeks, during which the changes in symptoms will be monitored and compared to the initial state before the treatment started.

Another medication involved in the study is Dexamethasone, which is a tablet form of a chemical substance used in various treatments. However, the main focus of this trial is on the LYR-210 System. Participants will be monitored for any changes in their symptoms and overall health to determine the safety and effectiveness of the treatment. The study aims to provide valuable information on whether the LYR-210 System can be a beneficial treatment option for those suffering from chronic sinusitis.

]]> Study on Azithromycin for Treating Chronic Sinusitis in Adults https://clinicaltrials.eu/trial/study-on-azithromycin-for-treating-chronic-sinusitis-in-adults/ Wed, 29 Apr 2026 14:23:05 +0000 https://clinicaltrials.eu/trial/study-on-azithromycin-for-treating-chronic-sinusitis-in-adults/ This clinical trial is focused on studying a condition known as chronic rhinosinusitis, which is a long-lasting inflammation of the sinuses that can cause symptoms like nasal congestion, facial pain, and a runny nose. The study is specifically looking at a type of chronic rhinosinusitis that is resistant to standard treatments and involves persistent pus-like discharge. The treatment being tested is a medication called azithromycin, which is an antibiotic commonly used to treat bacterial infections. Participants in the study will receive either azithromycin or a placebo, which is a substance with no active medication.

The purpose of the study is to evaluate the effectiveness of a three-month continuous treatment with azithromycin in improving the quality of life for adults with this type of sinusitis. The study will involve regular assessments of participants’ symptoms and overall health. Participants will be monitored over the course of the treatment to see how their symptoms change and to ensure their safety.

Throughout the study, various aspects of the participants’ health will be measured, including the frequency of sinus infections, the need for additional antibiotics, and changes in symptoms. The study will also look at the impact of the treatment on participants’ daily lives, such as their ability to work and their sense of smell. The goal is to determine whether azithromycin can provide significant relief for those suffering from chronic rhinosinusitis.

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