Chronic left ventricular failure – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:18:01 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Chronic left ventricular failure – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of cardiac atrial stem cells injected into heart muscle for treating advanced heart failure in patients with prior heart attack and reduced heart function https://clinicaltrials.eu/trial/study-of-cardiac-atrial-stem-cells-injected-into-heart-muscle-for-treating-advanced-heart-failure-in-patients-with-prior-heart-attack-and-reduced-heart-function/ Wed, 29 Apr 2026 15:06:28 +0000 https://clinicaltrials.eu/trial/study-of-cardiac-atrial-stem-cells-injected-into-heart-muscle-for-treating-advanced-heart-failure-in-patients-with-prior-heart-attack-and-reduced-heart-function/ This study focuses on treating patients with heart failure, specifically those who have experienced a myocardial infarction (heart attack) and have reduced heart function. The treatment being investigated involves injecting special cells called cardiac atrial stem cells directly into the heart muscle. These cells are obtained from donor heart tissue and are being tested to help improve heart function in patients with damaged heart tissue.

The purpose of this research is to evaluate whether injecting these stem cells into the heart muscle is safe for patients with advanced heart failure. The treatment involves a surgical procedure where the cells are injected directly into specific areas of the heart that have been damaged by the previous heart attack. The study will monitor patients for any heart-related complications and track their overall health after receiving the treatment.

During the study, patients will receive the stem cell treatment along with their standard heart care. The research team will perform various tests to check heart function, including echocardiography (heart ultrasound) and magnetic resonance imaging (MRI) scans. Patients will be monitored regularly after the procedure to assess their recovery and any changes in their heart condition.

]]> Study on Vericiguat for Children with Heart Failure Due to Left Ventricular Systolic Dysfunction https://clinicaltrials.eu/trial/study-on-vericiguat-for-children-with-heart-failure-due-to-left-ventricular-systolic-dysfunction/ Wed, 29 Apr 2026 14:24:47 +0000 https://clinicaltrials.eu/trial/study-on-vericiguat-for-children-with-heart-failure-due-to-left-ventricular-systolic-dysfunction/ This clinical trial is focused on studying heart failure in children and teenagers. Heart failure is a condition where the heart is unable to pump blood effectively. The study is specifically looking at heart failure caused by a problem with the left side of the heart, known as left ventricular systolic dysfunction. The treatment being tested is a medication called Vericiguat, which is taken orally either as a tablet or an oral suspension. Vericiguat is also known by its code name MK-1242.

The purpose of the study is to evaluate how well Vericiguat works in improving heart function in young patients with heart failure. Participants in the study will be randomly assigned to receive either Vericiguat or a placebo. The study will last for several weeks, during which time participants will take the medication and have regular check-ups to monitor their heart health and overall well-being. The study aims to see if Vericiguat can help reduce levels of a specific heart-related protein called NT-proBNP, which is often higher in people with heart failure.

Throughout the study, participants will be closely monitored for any side effects or changes in their condition. The study will also gather information on how the body processes Vericiguat, including how long it stays in the body and how it is cleared. This information will help determine the safety and effectiveness of Vericiguat for treating heart failure in children and teenagers.

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