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	<title>Cerebrospinal fluid circulation disorder &#8211; European Clinical Trials Information Network</title>
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	<title>Cerebrospinal fluid circulation disorder &#8211; European Clinical Trials Information Network</title>
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		<title>Study on Gadobutrol for Patients with Idiopathic Normal Pressure Hydrocephalus to Understand Cerebrospinal Fluid Movement Using MRI</title>
		<link>https://clinicaltrials.eu/trial/study-on-gadobutrol-for-patients-with-idiopathic-normal-pressure-hydrocephalus-to-understand-cerebrospinal-fluid-movement-using-mri/</link>
		
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		<pubDate>Wed, 29 Apr 2026 15:04:06 +0000</pubDate>
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					<description><![CDATA[This clinical trial is focused on studying a condition known as idiopathic normal pressure hydrocephalus (INPH), which is a disorder related to the circulation of cerebrospinal fluid in the brain. The study will use a medication called Gadovist, which is a solution for injection containing the active substance gadobutrol. This medication is used as a [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on studying a condition known as <i>idiopathic normal pressure hydrocephalus</i> (INPH), which is a disorder related to the circulation of cerebrospinal fluid in the brain. The study will use a medication called <i>Gadovist</i>, which is a solution for injection containing the active substance <i>gadobutrol</i>. This medication is used as a contrast agent in <i>MRI</i> scans to help visualize the transportation of cerebrospinal fluid in the brain.</p>
<p>The purpose of the study is to understand how the contrast agent distributes and is eliminated in the body, as observed through repeated MRI scans. The study will also monitor any side effects that may occur from the administration of Gadovist. Participants will receive an injection of the contrast agent into the spinal canal, and then undergo a series of MRI scans to track the movement and clearance of the contrast in the brain.</p>
<p>Throughout the study, researchers will analyze changes in the MRI images to gain insights into the dynamics of cerebrospinal fluid movement. This information could help improve understanding of the condition and potentially lead to better treatment options for patients with INPH. The study will also compare the distribution of the contrast agent with other MRI sequences and fluid dynamics parameters to explore possible mechanisms driving the distribution of cerebrospinal fluid.</p>
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