Cardiac failure congestive – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 04:13:32 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Cardiac failure congestive – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of cardiac atrial stem cells injected into heart muscle for treating advanced heart failure in patients with prior heart attack and reduced heart function https://clinicaltrials.eu/trial/study-of-cardiac-atrial-stem-cells-injected-into-heart-muscle-for-treating-advanced-heart-failure-in-patients-with-prior-heart-attack-and-reduced-heart-function/ Wed, 29 Apr 2026 15:06:28 +0000 https://clinicaltrials.eu/trial/study-of-cardiac-atrial-stem-cells-injected-into-heart-muscle-for-treating-advanced-heart-failure-in-patients-with-prior-heart-attack-and-reduced-heart-function/ This study focuses on treating patients with heart failure, specifically those who have experienced a myocardial infarction (heart attack) and have reduced heart function. The treatment being investigated involves injecting special cells called cardiac atrial stem cells directly into the heart muscle. These cells are obtained from donor heart tissue and are being tested to help improve heart function in patients with damaged heart tissue.

The purpose of this research is to evaluate whether injecting these stem cells into the heart muscle is safe for patients with advanced heart failure. The treatment involves a surgical procedure where the cells are injected directly into specific areas of the heart that have been damaged by the previous heart attack. The study will monitor patients for any heart-related complications and track their overall health after receiving the treatment.

During the study, patients will receive the stem cell treatment along with their standard heart care. The research team will perform various tests to check heart function, including echocardiography (heart ultrasound) and magnetic resonance imaging (MRI) scans. Patients will be monitored regularly after the procedure to assess their recovery and any changes in their heart condition.

]]> Study on Vitamin D and Oral Iron for Patients with Chronic Heart Failure and Iron Deficiency https://clinicaltrials.eu/trial/study-on-vitamin-d-and-oral-iron-for-patients-with-chronic-heart-failure-and-iron-deficiency/ Wed, 29 Apr 2026 15:02:39 +0000 https://clinicaltrials.eu/trial/study-on-vitamin-d-and-oral-iron-for-patients-with-chronic-heart-failure-and-iron-deficiency/ This clinical trial is focused on patients with chronic heart failure and iron deficiency. The study aims to evaluate the effectiveness of combining vitamin D with an oral iron supplement called sucrosomial iron compared to an intravenous iron treatment known as ferric carboxymaltose. The goal is to see if the combination of vitamin D and sucrosomial iron can improve heart failure symptoms as effectively as ferric carboxymaltose.

Participants in the study will receive either the vitamin D and sucrosomial iron combination or the ferric carboxymaltose treatment. The study will last for 24 weeks, during which the effects of these treatments on heart failure symptoms will be monitored. The main focus will be on the distance participants can walk in six minutes, which is a common way to assess physical ability in heart failure patients. Other aspects, such as quality of life and heart function, will also be evaluated.

The study will help determine if the oral combination of vitamin D and sucrosomial iron is a viable alternative to the intravenous iron treatment for improving the health of patients with chronic heart failure and iron deficiency. This research could provide valuable insights into more accessible treatment options for managing these conditions.

]]> Study on the Effects of Sacubitril/Valsartan and Ramipril on Heart Function in Patients with Ischemic Heart Failure with Mid-Range Ejection Fraction https://clinicaltrials.eu/trial/study-on-the-effects-of-sacubitril-valsartan-and-ramipril-on-heart-function-in-patients-with-ischemic-heart-failure-with-mid-range-ejection-fraction/ Wed, 29 Apr 2026 15:02:38 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-sacubitril-valsartan-and-ramipril-on-heart-function-in-patients-with-ischemic-heart-failure-with-mid-range-ejection-fraction/ This clinical trial is focused on studying the effects of two medications, sacubitril and valsartan, compared to ramipril, in patients with a specific type of heart failure known as heart failure with moderately reduced ejection fraction (HFmrEF). This condition affects the heart’s ability to pump blood effectively, and the study aims to understand how these medications can impact heart function and structure over time.

The purpose of the study is to evaluate how sacubitril/valsartan and ramipril affect the heart’s left ventricle, which is the main pumping chamber. The study will look at changes in the size and function of the left ventricle using a special imaging technique called magnetic resonance imaging (MRI). Participants will be treated for 12 months, and the study will monitor changes in heart function and any hospitalizations related to heart failure during this period.

Participants will take the medications orally, and the study will involve regular check-ups to assess heart health and any side effects. The trial will also include a comparison with a placebo, which is a substance with no active medication, to better understand the effects of the treatments. The study aims to provide valuable insights into the management of ischemic heart failure, which is heart failure caused by reduced blood flow to the heart.

]]> Study on the Effects of Dobutamine and Levosimendan in Patients with Heart Failure and Reduced Left Ventricular Function https://clinicaltrials.eu/trial/study-on-the-effects-of-dobutamine-and-levosimendan-in-patients-with-heart-failure-and-reduced-left-ventricular-function/ Wed, 29 Apr 2026 15:02:34 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-dobutamine-and-levosimendan-in-patients-with-heart-failure-and-reduced-left-ventricular-function/ This clinical trial is focused on studying the effects of two medications, dobutamine and levosimendan, in the treatment of heart failure. Heart failure is a condition where the heart is unable to pump blood effectively, leading to symptoms like shortness of breath and fatigue. The study specifically looks at patients with a reduced ability of the heart’s left ventricle to pump blood, known as depressed left ventricular ejection fraction.

The purpose of the study is to compare how these two medications affect the heart and blood vessels. Participants will receive either dobutamine or levosimendan, both administered intravenously, meaning they are given directly into a vein. The study will observe changes in the pressure within the lungs’ blood vessels and the amount of blood the heart pumps. These observations will help understand how each medication works in the current treatment context for heart diseases.

Throughout the study, participants will be monitored for various health indicators, including heart function and overall well-being. The study will last for a period of time, during which participants will have regular check-ups to assess their heart’s performance and any side effects from the medications. The goal is to gather information that could improve treatment options for people with heart failure.

]]> Study on Peritoneal Ultrafiltration with PolyCore for Patients with Congestive Heart Failure Using Levocarnitine and Drug Combination https://clinicaltrials.eu/trial/study-on-peritoneal-ultrafiltration-with-polycore-for-patients-with-congestive-heart-failure-using-levocarnitine-and-drug-combination/ Wed, 29 Apr 2026 14:29:24 +0000 https://clinicaltrials.eu/trial/study-on-peritoneal-ultrafiltration-with-polycore-for-patients-with-congestive-heart-failure-using-levocarnitine-and-drug-combination/ This clinical trial is focused on studying a condition known as , which is a type of heart disease where the heart is unable to pump blood effectively. The study will use a treatment called with a solution named . This solution is used in a process called peritoneal dialysis, which helps remove excess fluid from the body. contains several substances, including , , , , , , and . These ingredients work together to help manage fluid levels in the body.

The purpose of this study is to evaluate whether treatment with using can impact the health outcomes of patients with . The study will monitor patients to see if the treatment affects their overall health, including the risk of hospitalization or worsening of their condition. Participants will receive the treatment over a period of time, and their health will be regularly assessed to gather information on the treatment’s effectiveness and safety.

Throughout the study, participants will undergo various assessments, such as measuring their ability to walk a certain distance and evaluating their quality of life. The study will also track changes in specific health markers, like levels of certain proteins in the blood that are related to heart function. The goal is to determine if with can help improve the management of and potentially reduce the need for other treatments, such as intravenous diuretics or hemodialysis.

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