Breast cancer in situ – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:16:55 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Breast cancer in situ – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Breast Cancer Prevention in High-Risk Women Using Low Dose Tamoxifen and Lifestyle Changes https://clinicaltrials.eu/trial/study-on-breast-cancer-prevention-in-high-risk-women-using-low-dose-tamoxifen-and-lifestyle-changes/ Wed, 29 Apr 2026 15:05:49 +0000 https://clinicaltrials.eu/trial/study-on-breast-cancer-prevention-in-high-risk-women-using-low-dose-tamoxifen-and-lifestyle-changes/ This clinical trial is focused on preventing breast cancer in women who are at an increased risk. The study involves the use of a medication called Low Dose Tamoxifen, which is a type of drug that can help in reducing the risk of developing breast cancer. Participants in the study may also be asked to make changes to their diet and lifestyle, which could include adjustments to their eating habits and physical activity levels.

The purpose of the study is to determine if Low Dose Tamoxifen can increase the levels of a protein in the blood called Sex Hormone Binding Globulin (SHBG) more effectively than lifestyle changes alone. The study will involve women who are healthy but have a higher risk of breast cancer due to genetic factors or previous medical conditions. These women may carry certain genetic mutations, such as BRCA1 or BRCA2, or have a history of conditions like intraepithelial neoplasia, which is a type of abnormal cell growth in the breast.

Participants will be randomly assigned to one of four groups, where they will receive either Low Dose Tamoxifen, lifestyle changes, or a combination of both. The study will last for several months, during which time participants will have regular check-ups to monitor their health and the levels of various substances in their blood. The main focus will be on the levels of SHBG, but other factors such as insulin, glucose, and body composition will also be observed. The study aims to provide valuable insights into how these interventions can help in the prevention of breast cancer.

]]> Study on Detecting and Classifying Breast Disease Using Iodixanol in Digital Mammography and Tomosynthesis Compared to MRI in Patients with Breast Pathology https://clinicaltrials.eu/trial/study-on-detecting-and-classifying-breast-disease-using-iodixanol-in-digital-mammography-and-tomosynthesis-compared-to-mri-in-patients-with-breast-pathology/ Wed, 29 Apr 2026 15:02:36 +0000 https://clinicaltrials.eu/trial/study-on-detecting-and-classifying-breast-disease-using-iodixanol-in-digital-mammography-and-tomosynthesis-compared-to-mri-in-patients-with-breast-pathology/ This clinical trial focuses on studying the detection and classification of breast lesions using different imaging techniques. The study involves comparing Digital Mammography with Contrast Medium (CEDM), both alone and combined with Tomosynthesis, to Magnetic Resonance Imaging (MRI) that uses a substance called Gadolinium. The main goal is to evaluate how well these methods can identify and accurately diagnose breast conditions, including the presence of multiple tumors in one or both breasts.

The trial uses a special contrast agent called Visipaque, which contains the active substance iodixanol. This agent is injected into the body to help highlight areas of interest during imaging. The study aims to determine if CEDM, with or without tomosynthesis, is as effective as MRI in detecting and diagnosing breast lesions. Additionally, the study will assess the ability of these imaging techniques to classify breast lesions as benign or malignant and to identify specific tumor characteristics, such as luminal A, luminal B, HER2-positive, and triple-negative types.

Participants in the study will undergo imaging tests using the different methods mentioned. The study will compare the results to see which method provides the most accurate information about breast lesions. This research is important for improving the diagnosis and treatment planning for individuals with breast conditions, potentially leading to better outcomes and more personalized care.

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