BRCA1 gene mutation – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 04:14:53 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png BRCA1 gene mutation – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Denosumab to Prevent Breast Cancer in Women with BRCA1 Mutation https://clinicaltrials.eu/trial/study-on-denosumab-to-prevent-breast-cancer-in-women-with-brca1-mutation/ Wed, 29 Apr 2026 15:05:34 +0000 https://clinicaltrials.eu/trial/study-on-denosumab-to-prevent-breast-cancer-in-women-with-brca1-mutation/ This clinical trial is focused on the prevention of breast cancer in women who carry a specific genetic change known as the BRCA1 germline mutation. The study is investigating whether a medication called Denosumab, which is given as a solution for injection, can help prevent the development of breast cancer in these women. Denosumab is a type of protein-based medication that is already used for other medical conditions.

The purpose of the study is to see if Denosumab can reduce the risk of developing any type of breast cancer, including invasive breast cancer or a condition called DCIS (ductal carcinoma in situ), which is an early form of breast cancer. Participants in the study will receive either Denosumab or a placebo, and the study will compare the outcomes between these two groups. The study will also look at other health outcomes, such as the time it takes for any breast cancer to develop, the occurrence of other types of cancer, and the frequency of breast biopsies.

The study will take place over several years, with participants receiving regular injections and undergoing health assessments to monitor for any signs of breast cancer or other health changes. The goal is to gather information that could lead to new ways to prevent breast cancer in women with the BRCA1 mutation.

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