Brain neoplasm – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:19:38 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Brain neoplasm – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of Tarlatamab and Temozolomide combination treatment in adolescents and adults with high grade brain tumors https://clinicaltrials.eu/trial/study-of-tarlatamab-and-temozolomide-combination-treatment-in-adolescents-and-adults-with-high-grade-brain-tumors/ Wed, 29 Apr 2026 15:07:22 +0000 https://clinicaltrials.eu/trial/study-of-tarlatamab-and-temozolomide-combination-treatment-in-adolescents-and-adults-with-high-grade-brain-tumors/ This clinical trial focuses on treating patients with high grade brain tumors using a combination of two medications. The study will test Tarlatamab (also known as AMG 757), which is given through an intravenous infusion, together with Temozolomide, which is taken by mouth. These medications will be used to treat different types of brain tumors, including those with specific genetic changes.

The purpose of this study is to determine if this combination of medications is safe to use and to evaluate how well it works in treating brain tumors. The study is divided into two parts. The first part will check the safety of combining these medications, while the second part will look at how effective this treatment is in different groups of patients with various types of brain tumors.

During the study, patients will receive both medications according to a specific schedule. Tarlatamab will be given as an infusion into a vein, while Temozolomide will be taken as regular oral doses. The treatment will continue while patients are benefiting from it and not experiencing unacceptable side effects. Doctors will monitor patients’ responses to the treatment using brain scans and regular health checks throughout the study period.

]]> Study on Antibiotics Amoxicillin, Clavulanic Acid, Ciprofloxacin, and Drug Combination for Children with Malignant Brain Tumors https://clinicaltrials.eu/trial/study-on-antibiotics-amoxicillin-clavulanic-acid-ciprofloxacin-and-drug-combination-for-children-with-malignant-brain-tumors/ Wed, 29 Apr 2026 15:02:31 +0000 https://clinicaltrials.eu/trial/study-on-antibiotics-amoxicillin-clavulanic-acid-ciprofloxacin-and-drug-combination-for-children-with-malignant-brain-tumors/ This clinical trial focuses on children with malignant brain tumors, which are aggressive growths in the brain that can spread to other areas. The study aims to understand how different antibiotics behave in the body, specifically in the cerebrospinal fluid (CSF)</b), which is the fluid surrounding the brain and spinal cord. The antibiotics being studied include amoxicillin, clavulanic acid, ciprofloxacin, sulfamethoxazole, trimethoprim, cefotaxime sodium, fosfomycin, cefuroxime sodium, ceftriaxone sodium, linezolid, vancomycin, meropenem anhydrous, and gentamicin. These medications are used to treat infections and are administered either orally or through an intravenous infusion, which means they are given directly into a vein.

The purpose of the study is to measure the levels of these antibiotics in the CSF and blood plasma after they are administered to children with brain tumors that have spread or are at risk of spreading to the lining of the brain and spinal cord. This will help researchers understand how well these antibiotics can reach the CSF and potentially treat infections in this area. The study will involve regular monitoring of antibiotic levels in the body over a period of time to gather data on how the drugs are distributed and how long they stay active in the CSF.

Participants in the study will receive either the antibiotics or a placebo, and their progress will be closely monitored by medical professionals. The study is designed to provide valuable information that could improve the treatment of infections in children with brain tumors, helping to ensure that the antibiotics used are effective in reaching the areas where they are needed most. This research is important for developing better treatment strategies for managing infections in children with these serious conditions.

]]> Safety Study of 5-Aminolevulinic Acid for Brain Tumor Surgery in Children and Adolescents https://clinicaltrials.eu/trial/safety-study-of-aminolevulinic-acid-hydrochloride-for-children-and-adolescents-with-brain-tumors/ Wed, 29 Apr 2026 14:58:09 +0000 https://clinicaltrials.eu/trial/safety-study-of-aminolevulinic-acid-hydrochloride-for-children-and-adolescents-with-brain-tumors/ This clinical trial focuses on children and adolescents with brain tumors. The study will evaluate the safety of a medicine called 5-Aminolevulinic acid (5-ALA), available as Gliolan, which comes as a powder that is mixed with liquid and taken by mouth. This medicine helps surgeons see tumor tissue more clearly during brain surgery by making the tumor cells glow under special light.

The main purpose of this research is to determine if 5-ALA can be safely used for surgery in young patients when removing tumors from the brain. During the study, patients will receive a single dose of the medication before their scheduled brain surgery. The medicine is given at a dose based on the patient’s body weight, up to 20 milligrams per kilogram.

After taking the medicine, patients will undergo brain surgery where doctors will use special lighting to help them see and remove the tumor tissue. The study will monitor patients for any side effects or complications that may occur during and after the surgery. Some patients may also have blood samples taken to understand how the medicine works in young bodies.

]]> Study on Lithium Sulphate to Prevent Cognitive Impairment in Children After Brain Tumor Radiotherapy https://clinicaltrials.eu/trial/study-on-lithium-sulphate-to-prevent-cognitive-impairment-in-children-after-brain-tumor-radiotherapy/ Wed, 29 Apr 2026 14:24:26 +0000 https://clinicaltrials.eu/trial/study-on-lithium-sulphate-to-prevent-cognitive-impairment-in-children-after-brain-tumor-radiotherapy/ This clinical trial is focused on studying the effects of a medication called Lithionit, which contains the active ingredient lithium sulphate. The study is aimed at children who have undergone brain radiotherapy for a brain tumor. The purpose of the study is to see if Lithionit can help prevent problems with thinking and processing information that might appear after such treatment.

Participants in the study will receive either Lithionit or a placebo, which looks like the medication but does not contain the active ingredient. The study will last for several years, with regular check-ups to monitor the participants’ cognitive abilities, which means their ability to think, learn, and remember. These check-ups will include various tests to measure different aspects of brain function, such as processing speed and memory. The study will also use MRI scans to look at changes in the brain over time.

The goal is to understand if Lithionit can help maintain or improve cognitive function in children who have had brain radiotherapy. This research is important because it could lead to better treatments for preventing cognitive issues in young patients who have received such treatments for brain tumors.

]]> Study of Nivolumab with Chemotherapy for Children and Teenagers with Refractory or Relapsing Solid Tumors or Lymphoma https://clinicaltrials.eu/trial/study-of-nivolumab-with-chemotherapy-for-children-and-teenagers-with-refractory-or-relapsing-solid-tumors-or-lymphoma/ Wed, 29 Apr 2026 14:23:09 +0000 https://clinicaltrials.eu/trial/study-of-nivolumab-with-chemotherapy-for-children-and-teenagers-with-refractory-or-relapsing-solid-tumors-or-lymphoma/ This clinical trial is focused on studying treatments for children and teenagers with refractory or relapsing solid tumors. These are types of cancer that have not responded to standard treatments or have returned after treatment. The study will explore the use of a medication called Nivolumab, which is an anti-PD1 drug, in combination with different chemotherapy regimens. Chemotherapy is a type of cancer treatment that uses drugs to destroy cancer cells. The chemotherapy drugs being tested in this study include Cyclophosphamide, Vinblastine, and Capecitabine. These drugs will be given in a specific way called metronomic chemotherapy, which involves taking lower doses of chemotherapy drugs more frequently.

The purpose of the study is to find out which combination of these treatments is safe and effective for young patients with these challenging types of cancer. In the first stage of the study, researchers will determine which of the three chemotherapy regimens is safe to use with Nivolumab. The regimens being tested are: Cyclophosphamide and Vinblastine; Capecitabine alone; and a combination of Cyclophosphamide, Vinblastine, and Capecitabine. In the second stage, the study will focus on the most promising regimen from the first stage, with or without Nivolumab, to see how well it works in preventing the cancer from getting worse.

Participants in the study will receive their treatments either through an intravenous method, which means the medication is given directly into a vein, or orally, which means taking the medication by mouth. The study will monitor the participants over time to assess the safety of the treatments and their effectiveness in controlling the cancer. The study aims to provide valuable information that could lead to better treatment options for children and teenagers facing these difficult cancers.

]]> Hjernesvulstforeningen https://clinicaltrials.eu/organisation/hjernesvulstforeningen/ Wed, 29 Apr 2026 13:34:18 +0000 https://clinicaltrials.eu/organisation/hjernesvulstforeningen/ The Hjernesvulstforeningen (Norwegian Brain Tumor Association) is a voluntary, nationwide patient and user organization. Its main goal is to support individuals affected by brain tumors and their closest relatives. They also work to spread knowledge about living with a brain tumor diagnosis. The organization’s activities include peer support, information dissemination, advocacy, and supporting research—all for the benefit of those affected by the disease and their loved ones.

]]> Brainstrust – The Brain Cancer People https://clinicaltrials.eu/organisation/brainstrust-the-brain-cancer-people/ Wed, 29 Apr 2026 13:34:18 +0000 https://clinicaltrials.eu/organisation/brainstrust-the-brain-cancer-people/ Brainstrust is a brain tumor charity dedicated to helping individuals living with a brain tumor reach their potential and thrive. The organization offers a variety of support, including a 24/7 helpline and online resources covering treatment information, practical assistance (like travel and financial matters), and guidance on living well with a brain tumor (including exercise, mindfulness, and coaching). They also provide tailored support for specific tumor types such as Acoustic Neuroma, Glioblastoma, and Meningioma.

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