Benign prostatic hyperplasia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:14:52 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Benign prostatic hyperplasia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Antibiotic Treatment Before Surgery for Benign Prostate Hyperplasia: Fosfomycin Calcium, Bromhexine Hydrochloride, Sulfamethoxazole, and Trimethoprim https://clinicaltrials.eu/trial/study-on-antibiotic-treatment-before-surgery-for-benign-prostate-hyperplasia-fosfomycin-calcium-bromhexine-hydrochloride-sulfamethoxazole-and-trimethoprim/ Wed, 29 Apr 2026 15:03:35 +0000 https://clinicaltrials.eu/trial/study-on-antibiotic-treatment-before-surgery-for-benign-prostate-hyperplasia-fosfomycin-calcium-bromhexine-hydrochloride-sulfamethoxazole-and-trimethoprim/ This clinical trial is focused on studying the treatment of Benign Prostate Hyperplasia (BPH), a condition where the prostate gland is enlarged, causing urinary problems. The study will explore the use of antibiotics before undergoing endoscopic surgery for BPH. The antibiotics being studied include Fosfomycin Calcium and a combination of Bromhexine Hydrochloride, Sulfamethoxazole, and Trimethoprim. These medications are commonly used to treat infections and will be compared to a placebo to see if they help reduce the risk of urinary tract infections after surgery.

The purpose of the study is to determine if not using antibiotics before surgery is just as effective as using them in preventing urinary tract infections within one month after the procedure. Participants will be randomly assigned to receive either the antibiotics or a placebo. The study will monitor the occurrence of urinary infections, characterized by symptoms like burning during urination, fever, and urgency, along with the presence of bacteria in the urine.

Throughout the study, researchers will also look at other factors, such as the number of surgeries canceled, the types of bacteria involved, and the costs associated with antibiotic treatment. The study aims to provide insights into whether the experimental approach is both clinically and economically comparable to the standard treatment. This research could potentially influence future prescribing practices for patients undergoing surgery for BPH.

]]> Study on the Safety and Effectiveness of Oxitriptan and Tamsulosin Hydrochloride for Patients with Benign Prostatic Hyperplasia https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-oxitriptan-and-tamsulosin-hydrochloride-for-patients-with-benign-prostatic-hyperplasia/ Wed, 29 Apr 2026 14:58:08 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-oxitriptan-and-tamsulosin-hydrochloride-for-patients-with-benign-prostatic-hyperplasia/ This clinical trial is focused on studying the effects of a treatment for Benign Prostatic Hyperplasia (BPH), a condition where the prostate gland is enlarged, which can cause urinary problems. The study will use a treatment involving tryptophan, a substance that is being evaluated for its potential to improve symptoms related to BPH. The trial will also involve the use of tamsulosin hydrochloride, a medication commonly used to treat BPH symptoms.

The purpose of the study is to assess the safety and effectiveness of tryptophan in patients with BPH. Participants will receive either tryptophan or a placebo, alongside their regular treatment with tamsulosin hydrochloride. The study will last for a period of six months, during which participants will take the medication orally in the form of capsules or tablets. The study aims to observe changes in urinary symptoms and overall quality of life related to urinary health.

Throughout the study, participants will be monitored for any changes in their condition, including improvements in urinary flow and prostate size. The study will use the International Prostate Symptom Score (IPSS) to evaluate the severity of urinary symptoms. This trial is an important step in understanding how tryptophan might help manage symptoms of BPH and improve the lives of those affected by this condition.

]]> Study on How Degarelix and Drug Combination Affect Gut Health in Patients with Prostate Cancer or Benign Prostate Hyperplasia https://clinicaltrials.eu/trial/study-on-how-degarelix-and-drug-combination-affect-gut-health-in-patients-with-prostate-cancer-or-benign-prostate-hyperplasia/ Wed, 29 Apr 2026 14:25:14 +0000 https://clinicaltrials.eu/trial/study-on-how-degarelix-and-drug-combination-affect-gut-health-in-patients-with-prostate-cancer-or-benign-prostate-hyperplasia/ This clinical trial is focused on studying the effects of medications used to treat prostate cancer and benign prostate hyperplasia, which is a non-cancerous enlargement of the prostate gland. The study will involve medications such as FIRMAGON (containing the active substance degarelix), Duodart (containing tamsulosin hydrochloride and dutasteride), and FINASTERIDE. These medications are used to manage symptoms and progression of prostate conditions. The purpose of the study is to understand how these prostate medications interact with the gut microbiota, which is the community of microorganisms living in the intestines.

Participants in the study will receive one of the medications mentioned above. FIRMAGON is administered as an injection under the skin, while Duodart and FINASTERIDE are taken orally in capsule or tablet form. The study will last for a period of up to six months, during which the effects of the medications on the gut microbiota will be observed. The gut microbiota plays a crucial role in digestion and overall health, and this study aims to see how it is affected by prostate treatments.

Throughout the study, changes in the gut microbiota will be monitored, along with other factors such as prostate-specific antigen (PSA) levels and prostate volume. PSA is a protein produced by the prostate gland, and its levels can indicate changes in prostate health. By understanding these interactions, the study hopes to provide insights into how prostate treatments can influence gut health and metabolism. Participants will be closely monitored to ensure their safety and well-being during the trial.

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