Bacterial vaginosis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Wed, 17 Jun 2026 04:02:54 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Bacterial vaginosis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Using a drug combination to treat vaginal flora abnormalities in pregnant women at high risk of preterm birth. https://clinicaltrials.eu/trial/using-a-drug-combination-to-treat-vaginal-flora-abnormalities-in-pregnant-women-at-high-risk-of-preterm-birth/ Wed, 29 Apr 2026 15:09:46 +0000 https://clinicaltrials.eu/trial/using-a-drug-combination-to-treat-vaginal-flora-abnormalities-in-pregnant-women-at-high-risk-of-preterm-birth/ This study focuses on pregnant women who are at a high risk of preterm birth, which is a birth that occurs before 37 weeks of pregnancy. The research looks at individuals with vaginal flora abnormalities, meaning an imbalance in the natural bacteria found in the vagina, and Bacterial vaginosis, a common condition caused by an overgrowth of certain bacteria. The purpose of the study is to evaluate if using a new testing method to identify these imbalances early in pregnancy can help reduce the number of early births.

Participants may receive different treatments depending on their assigned group. Medications used in the study include clotrimazole, metronidazole, azithromycin, ceftriaxone, and doxycycline. Some treatments are taken by mouth as a tablet, while others are administered through an intramuscular injection, which is a shot given into a muscle, or as a vaginal capsule, which is a soft medication inserted into the vagina. Some participants may also receive a placebo instead of the active medication.

During the study, women will undergo screening to check for bacterial imbalances using molecular biology, a method used to look at the genetic material of bacteria to identify them. The course of the study involves monitoring the health of both the mother and the baby throughout the pregnancy and following the outcomes of the birth. This includes tracking various health factors such as the length of the pregnancy and any medical needs for the newborn.

]]> Study of chlorhexidine, metronidazole, and FB301 for the treatment of women with bacterial vaginosis https://clinicaltrials.eu/trial/study-of-chlorhexidine-metronidazole-and-fb301-for-the-treatment-of-women-with-bacterial-vaginosis/ Wed, 29 Apr 2026 15:09:13 +0000 https://clinicaltrials.eu/trial/study-of-chlorhexidine-metronidazole-and-fb301-for-the-treatment-of-women-with-bacterial-vaginosis/ This study is being conducted to evaluate the effect of certain treatments on the vaginal microbiome, which is the community of tiny organisms living in the vagina, in women diagnosed with Bacterial vaginosis. This condition occurs when there is an imbalance of the natural bacteria in the vagina. The research focuses on how different combinations of medications can help restore a healthy balance of beneficial bacteria.

The treatments involved include chlorhexidine, which is applied as a liquid solution, and metronidazole, which is taken as a pill. Following these initial treatments, the study uses a product known as FB301, which is provided in the form of a capsule. The goal is to see if using these medications together can increase the presence of healthy bacteria like Lactobacillus species.

During the study, participants will follow a specific sequence of using the different medications. Over several weeks, the changes in the vaginal environment will be monitored to determine if the treatments successfully restore a healthy microbial balance and resolve symptoms associated with the condition.

]]> A study comparing furazidin and clindamycin for women with bacterial vaginosis https://clinicaltrials.eu/trial/a-study-comparing-furazidin-and-clindamycin-for-women-with-bacterial-vaginosis/ Wed, 29 Apr 2026 15:08:40 +0000 https://clinicaltrials.eu/trial/a-study-comparing-furazidin-and-clindamycin-for-women-with-bacterial-vaginosis/ This study is looking at bacterial vaginosis, which is a common vaginal infection caused by an imbalance of bacteria. The study will compare two different treatments for this condition. One treatment is furazidin vaginal tablets, which contain a substance that stops bacteria from growing. The other treatment is clindamycin vaginal cream, which is an antibiotic that fights bacterial infections. Both medications are used by inserting them into the vagina. The treatment with either medication will last for 7 days.

The purpose of this study is to show that treatment with furazidin vaginal tablets works as well as treatment with clindamycin vaginal cream for bacterial vaginosis. During the study, women will be randomly assigned to receive either furazidin tablets or clindamycin cream. After completing the treatment, participants will attend several follow-up visits to check if the infection has cleared and to monitor for any side effects. The study will also check whether the infection comes back within 12 weeks after treatment ends.

The study will measure how many women are cured of the infection by checking for specific signs such as abnormal vaginal discharge, odor, and the presence of certain cells under a microscope. Additional measurements will include laboratory tests to confirm the infection is gone, tracking any unwanted side effects from the medications, and assessing how the treatment affects quality of life. Follow-up visits will continue for several months to monitor for any return of the infection.

]]> Study on the Effectiveness and Safety of Metronidazole, Neomycin Sulfate, and Nystatin for Women with Bacterial Vaginosis and Yeast Infections https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-metronidazole-neomycin-sulfate-and-nystatin-for-women-with-bacterial-vaginosis-and-yeast-infections/ Wed, 29 Apr 2026 14:57:38 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-metronidazole-neomycin-sulfate-and-nystatin-for-women-with-bacterial-vaginosis-and-yeast-infections/ This clinical trial is focused on studying the treatment of two common vaginal infections: bacterial vaginosis and vulvovaginal candidiasis. Bacterial vaginosis is an infection caused by an imbalance of bacteria in the vagina, while vulvovaginal candidiasis is a yeast infection. The study will compare the effectiveness and safety of two treatments: Metronidazole/Neomycin Sulfate/Nystatin pessaries and Tergynan vaginal tablets. Both treatments are designed to be used vaginally to help clear these infections.

The purpose of the study is to determine if the Metronidazole/Neomycin Sulfate/Nystatin pessaries are as effective and safe as the Tergynan vaginal tablets in treating these infections. Participants in the study will use one of these treatments for a period of 10 days. During this time, researchers will monitor the participants to see how well the infections respond to the treatment and to check for any side effects. The study aims to provide a better understanding of which treatment option is more effective in achieving a cure for these infections.

Participants will be asked to follow specific guidelines during the study, such as avoiding certain activities and products that could interfere with the treatment. The study will help determine the best treatment option for women suffering from bacterial vaginosis and vulvovaginal candidiasis, potentially leading to improved care and outcomes for these common conditions.

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