Aspergillus infection – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 23 Jun 2026 04:07:03 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Aspergillus infection – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study to evaluate the efficacy and safety of liposomal amphotericin B for patients with simple pulmonary aspergilloma https://clinicaltrials.eu/trial/study-to-evaluate-the-efficacy-and-safety-of-liposomal-amphotericin-b-for-patients-with-simple-pulmonary-aspergilloma/ Wed, 29 Apr 2026 15:09:28 +0000 https://clinicaltrials.eu/trial/study-to-evaluate-the-efficacy-and-safety-of-liposomal-amphotericin-b-for-patients-with-simple-pulmonary-aspergilloma/ This study focuses on individuals with simple pulmonary aspergilloma, which is a condition where a ball of fungus grows inside a cavity in the lungs. The purpose of the study is to evaluate the efficacy and safety of liposomal amphotericin B, a specialized form of an antifungal medication, when delivered directly into the airways. This method of delivery is known as intrabronchial instillation, which means the medicine is placed into the breathing tubes of the lungs.

During the course of the study, participants will receive the treatment and undergo assessments to monitor changes in the size of the fungal mass. The study will also look for signs of hemoptysis, which is the medical term for coughing up blood, and any other side effects that may occur during the process. Researchers will also monitor for any progression to more serious forms of chronic pulmonary aspergillosis, a broader type of long-term fungal lung infection.

]]> Study of fosmanogepix compared to standard antifungal drugs for treating invasive mold infections in adults https://clinicaltrials.eu/trial/study-of-fosmanogepix-compared-to-standard-antifungal-drugs-for-treating-invasive-mold-infections-in-adults/ Wed, 29 Apr 2026 15:06:23 +0000 https://clinicaltrials.eu/trial/study-of-fosmanogepix-compared-to-standard-antifungal-drugs-for-treating-invasive-mold-infections-in-adults/ This study focuses on treating invasive mold infections caused by various types of fungi, including Aspergillus, Fusarium, Lomentospora prolificans, and Mucorales fungi. The main treatment being tested is fosmanogepix, which will be given both as an infusion into a vein and as tablets by mouth. The study will compare fosmanogepix with other antifungal medications including voriconazole, anidulafungin, amphotericin B, rezafungin, micafungin, caspofungin, isavuconazole, posaconazole, and terbinafine.

The purpose of this research is to evaluate how well fosmanogepix works and how safe it is for treating adults who have serious fungal infections. The study will look at whether the treatment helps patients survive and recover from their infections. The treatment period can last up to 180 days, depending on how each patient responds.

During the study, doctors will monitor patients’ progress through various tests and examinations. They will check how well the infection responds to treatment by looking at clinical symptoms, laboratory tests, and imaging scans. They will also carefully track any side effects that may occur during treatment.

]]>